Genetic Flashcards Preview

Neuro 2 Midterm > Genetic > Flashcards

Flashcards in Genetic Deck (15):
1

Cell type affected in mitochondrial dz

Gray matter neuron

2

Globoid cell macrophages, 3-6mos, microglia

Krabbe Leukodystrophy

3

Lysosomal arylsulfatase A; blue urine

Metachromatic leukodystrophy

4

XLR, ABCD1 (ATP cassette transport), VLCFA, adrenal, behavior

ALD: adrenoleukodystrophy

5

Cytochrome C oxidase

Common of all mitochondrial dz: MRRF, MELAS, leigh

6

MTTL1 (tRNA leucine)

MELAS

7

Mitochondrial with death by 2

Leigh

8

Psychosis with acute ophthalmoplegia

Wernicke (b1 thiamine)

9

Subacute combined degeneration of spinal cord

B12

10

Bl numbness, tingling, symmetrical LE ataxia w/ weakness

Subacute combined degeneration of spinal cord

11

How does B12 def cause dz

Improper myelin formation

12

How do leukos cause dz

Catabolism of myelin is bad -- lysosome, peroxisome

13

Tropism, subacute combined degeneration of spinal cord

Mid thoracic spine

14

Tropism, CO

Internal capsule

15

Bergman gliosis of cerebellum

Wernicke-Korsakoff