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Flashcards in GI Drugs Deck (20):
1

H2 Blockers MOA and usage

Cimetidine, ranitidine, famotidine, nizatidine.

Used for peptic ulcer disease, gastritis, mild esophageal reflux.

2

H2 Blockers Side effect

Cimetidine is a potent Cyp 450 inhibitor, also has antiandrogenic effects like prolactin release, gynecomastia, impotence, decreased libido. These drugs can cross the BBB causing confusion, dizziness, headaches. Can also cross placenta.

Both cimetidine and ranitidine decrease creatinine clearance

3

PPIs

Omeprazole, esomeprazole. Irreversible inhibitors of the H-K atpase in parietal cells. Used for Ulcers, gastritis, esophageal reflux, ZE syndrome

4

Toxicity of PPIs

Increased risk of C.Diff infection, pneumonia, hip fractures, decrease in magnesium with long term use

5

Bismuth, sucralfate

Bind to ulcer base providing physical protection and allowing HCO3 to regenerate.

6

Misoprostol

PGE analog used to regenerate bicarb/mucous layer in stomach. Decreases acid production. Used to prevent NSAID induced peptic ulcers.

7

Adverse effects of misoprostol

An abortifactant, can cause diarrhea too

8

Octreotide

Somatostatin analog, prevents all secretions, can stop variceal bleeds.

9

Effects of antacid use

All can cause hypokalemia, can affect the pharmacokinetics of other drugs. Overuse can cause many problems

10

Aluminum hydroxide

Can cause constipation and hypophosphatemia, seizures, and muscle weakness

11

Calcium carbonate

Can cause hypercalcemia (depressed mood, fatigue, weakness). Can chelate and decrease effectiveness of tetracyclines

12

Magnesium hydroxide

Can cause diarrhea, hyporeflexia, cardiac arrest.

13

Infliximab

Monoclonal antibody to TNF alpha used in UC and CD, also RA, and Ankylosing spondylitis.

14

Toxicity of infliximab

Can cause infection (TB), fever, hypotension

15

Sulfasalazine

A combination of sulfapyridine and 5 ASA. Antibacterial and antiinflamatory. Used in UC and CD

16

Toxicity of sulfasalazine

Reversible oligospermia!!!!!!

17

Ondansetron

5HT3 receptor antagonist used for nausea, decreases vagal stimulation

18

Ondansetron side effects

Conspitpation and headaches

19

Metoclopramide

D2 antagonist, increases resting tone, contractility, LES tone, motility. DOESN"T INFLUENCE COLON motility. Used for gastroparesis and as an antiemetic

20

Metoclopramide side effects?

Parkinsonism, can interact with digoxin and diabetic agents. Don't use in PD or people with small bowel obstruction.