H2 blockers (4)
Cimetidine, Ranitidine, Famotidine, Nizatidine
H2 blockers mechanism
reversible block of histamine H2 receptors leading to decreased H+ secretion by parietal cells
H2 blockers clinical use
peptic ulcer gastritis mild reflux
-potent inhibitor of CYP450 -antiandrogenic effects (prolactin release, gynecomastia, impotence, decreased libido) -crosses BBB (confusion, HA) and placenta
Both Cimetidine and Ranitidine can...
decrease renal excretion of creatinine.
Proton pump inhibitors (5)
Omeprazole Lansoprazole Esomeprazole Pantoprazole Dexlansoprazole
irreversibly inhibit H+/K+ ATPase in stomach parietal cells
Clinical Use of PPIs
-peptic ulcer -gastritis -reflux -ZE syndrome
Toxicity of PPIs
-C. diff infxn -pneumonia -hip fractures -decreased magnesium
Bismuth and Sucralfate MOA
bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in mucous layer
Bismuth and Sucralfate Use
increases ulcer healing traveler's diarrhea
PGE1 analog that increases the production/secretion of gastric mucous barrier and decreases acid production
prevention of NSAID-induced peptic ulcers maintenance of PDA induce labor
Toxciity of Misoprostol
Misoprostol is contraindicated in...
women of childbearing potential because it is an abortifacient.
long-acting somatostatin analog
-acute variceal bleeds -acromegaly -VIPoma -carcinoid tumors
Toxicity of Octreotide
nausea cramps steatorrhea
Antacid use can affect the...
absorption, bioavailablity or urinary excretion of other drugs by altering gastric and urinary pH or by delaying gastric emptying.
All antacids can cause...
1. Aluminum hydroxide 2. Calcium carbonate 3. Magnesium hydroxide
Aluminum hydroxide overuse can cause...
constipation and hypophosphatemia, proximal muscle weakness, osteodystrophy and seizures
Overuse of calcium carbonate can cause...
hypercalcemia and cause a rebound acid increase.
Overuse of magnesium hydroxide can cause...
diarrhea, hyporeflexia, hypotension and cardiac arrest.
Osmotic laxatives (4)
1. magnesium hydroxide 2. magnesium citrate 3. polyethylene glycol 4. lactulose
Osmotic laxative MOA
provide osmotic load to draw water out
Lactulose also helps treat hepatic encephalopathy since...
gut flora degrade it into metabolites (lactic acid and acetic acid) that promote nitrogen excretion as NH4+.
monoclonal antibody to TNF-alpha
Infliximab clinical use
-Crohn's -UC -RA -ankylosing spondylitis -psoriasis