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Flashcards in GI drugs Deck (39)
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1

2

H2 blockers (4)

Cimetidine, Ranitidine, Famotidine, Nizatidine

3

H2 blockers mechanism

reversible block of histamine H2 receptors leading to decreased H+ secretion by parietal cells

4

H2 blockers clinical use

peptic ulcer gastritis mild reflux

5

Cimetidine toxicity

-potent inhibitor of CYP450 -antiandrogenic effects (prolactin release, gynecomastia, impotence, decreased libido) -crosses BBB (confusion, HA) and placenta

6

Both Cimetidine and Ranitidine can...

decrease renal excretion of creatinine.

7

Proton pump inhibitors (5)

Omeprazole Lansoprazole Esomeprazole Pantoprazole Dexlansoprazole

8

PPI MOA

irreversibly inhibit H+/K+ ATPase in stomach parietal cells

9

Clinical Use of PPIs

-peptic ulcer -gastritis -reflux -ZE syndrome

10

Toxicity of PPIs

-C. diff infxn -pneumonia -hip fractures -decreased magnesium

11

Bismuth and Sucralfate MOA

bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in mucous layer

12

Bismuth and Sucralfate Use

increases ulcer healing traveler's diarrhea

13

Misoprostol mechanism

PGE1 analog that increases the production/secretion of gastric mucous barrier and decreases acid production

14

Misoprostol use

prevention of NSAID-induced peptic ulcers maintenance of PDA induce labor

15

Toxciity of Misoprostol

diarrhea

16

Misoprostol is contraindicated in...

women of childbearing potential because it is an abortifacient.

17

Octreotide MOA

long-acting somatostatin analog

18

Octreotide Use

-acute variceal bleeds -acromegaly -VIPoma -carcinoid tumors

19

Toxicity of Octreotide

nausea cramps steatorrhea

20

Antacid use can affect the...

absorption, bioavailablity or urinary excretion of other drugs by altering gastric and urinary pH or by delaying gastric emptying.

21

All antacids can cause...

hypokalemia.

22

Antacids (3)

1. Aluminum hydroxide 2. Calcium carbonate 3. Magnesium hydroxide

23

Aluminum hydroxide overuse can cause...

constipation and hypophosphatemia, proximal muscle weakness, osteodystrophy and seizures

24

Overuse of calcium carbonate can cause...

hypercalcemia and cause a rebound acid increase.

25

Overuse of magnesium hydroxide can cause...

diarrhea, hyporeflexia, hypotension and cardiac arrest.

26

Osmotic laxatives (4)

1. magnesium hydroxide 2. magnesium citrate 3. polyethylene glycol 4. lactulose

27

Osmotic laxative MOA

provide osmotic load to draw water out

28

Lactulose also helps treat hepatic encephalopathy since...

gut flora degrade it into metabolites (lactic acid and acetic acid) that promote nitrogen excretion as NH4+.

29

Infliximab MOA

monoclonal antibody to TNF-alpha

30

Infliximab clinical use

-Crohn's -UC -RA -ankylosing spondylitis -psoriasis