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Flashcards in GI drugs Deck (14):
1

diphenoxylate

related to meperidine, anti-diarrheal opiate and slows motility. Side effects include bloating and sedation

2

Octreotide

Somatostatin analog; Secretory diarrhea, acromegaly, VIPoma, carcinoid, cariceal bleeds

3

Principle of bioavailability

fraction of administered drug that reaches systemic circulation in chemically unchanged form. TO calculate, oral plasma concentrations are compared to IV concentrations. (area under oral curve x IV dose) / (Area under IV curve x oral dose).

4

carcinoid syndrome treatment of symptoms

Give octreotide. This will help relieve the syndrome symptoms by inhibiting secretion of a bunch of hormones. It is also used to treat VIPomas

5

-tidine

Cimetidine, ranitidine, famotidine; H2 blockers. Side effects of cimetidine: P450 inhibition, antiandrogen (prolactin relese), can cross BBB (confusion, diziness, headaches).

6

-prazole

Omeprazole lanosprazole; proton pump blocker. ZE syndrome first line

7

Bismuth and sucrasulfate

bind to ulcer and provides protection. For ulcer healing and traveler's diarrhea

8

Misoprostol

PGE analog to increase production and secretion of gastric mucosa and decrease acid secretion. NSAID ulcer prophylaxis; PDA maintenance; induces labor; Contraindicated in women of childbearing potential

9

Antacids

Affect absorption of other drugs d/t changes in pH. Delay gastric emptying. Changes urinary excretion of drugs too. Aluminum hydroxide: constipation and hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures. Magnesium hydroxide- diarrhea, hyporeflexia, hypotension, cardiac arrest. Calcium carbonate - hypercalcemia and rebound acid increase, can chelate and decrease other drugs effectiveness. All can cause hypokalemia

10

Osmotic laxatives

Magnesium hydroxide, Magnesium citrate, polyethylene glycol, lactulose(also treats hepatic encephalopathy by flora conversion into lactic and acetic acid that promote excretion of nitrogen as ammonium); used for constipation. May be used by bulimics

11

Infliximab

antibody to TNF-alpha, for Crohn's and RA. Can reactivate latent TB

12

Sulfasalazine

combo of sulfapyridine (ABX) and 5-aminosalicylic acid (cox inhibitor) that is activated by bacterial digestion. Used for IBD. Sulfonamide toxicity, reversible oligospermia

13

Ondansetron

5HT-3 blocker. Central-acting antiemetic. Postoperative vomiting and for chemo adjunct. Constipation

14

Metoclopramide

D2 (G-inhibitory) blocker therefore increasing levels of cAMP. Increases contractility, LES tone, motility and resting tone. Doesn't influence colon transport time. For gastroparesis of diabetics and post-surgical. Increased parkinsonian effects. Interacts with digoxin and diabetic agents. Contraindicated in parkinson patients and those w small bowell obstruction