GI NT and Regulatory Substances Flashcards Preview

Gastrointestinal System > GI NT and Regulatory Substances > Flashcards

Flashcards in GI NT and Regulatory Substances Deck (42):
1

Source of NT 

Acetylcholine

Cholinergic neurons

2

Source of NT 

Norepinephrine

Adrenergic neurons

3

Source of NT 

Vasoactive Intestinal Peptide (VIP)

Mucosal neurons

4

Source of NT

Gastrin-Releasing Peptide (GRP)

Gastric neurons

5

Source of NT

Enkephalins

Mucosal neurons

6

Source of NT

Substance P

Secreted with ACh

7

Source of NT

Neuropeptide Y

Mucosal neurons

8

Action of NT

Acetylcholine

(5)

  1. Smooth muscle contraction
  2. Relaxation of spincters
  3. Increases salivary secretion
  4. Increases gastric secretion
  5. Increases pancreatic secretion

9

Action of NT

Norepinephrine

(3)

  1. Smooth muscle relaxation
  2. Contraction of sphincters
  3. Increases salivary secretion

10

Action of NT

Vasoactive Intestinal Peptide

(3)

  1. Smooth muscle relaxation
  2. Increases intestinal secretion
  3. Increases pancreatic secretion

11

Action of NT

Gastrin-Releasing Peptide (GRP)

(1)

  1. Increases gastrin secretion

12

Action of NT

Enkephalins

(2)

  1. Contraction of GI sphincters
  2. Decreases intestinal secretion

13

Action of NT

Substance P

(2)

  1. Smooth muscle contraction
  2. Increases salivary secretion

14

Action of NT

Neuropeptide Y

(2)

  1. Smooth muscle relaxation
  2. Decreases intestinal secretion

15

Site of secretion of GI hormone:

Gastrin

G cells of stomach

16

Site of secretion of GI hormone:

Cholecystokinin (CCK)

I cells of duodenum and jejunum

17

Site of secretion of GI hormone:

Secretin

S cells of duodenum

18

Site of secretion of GI hormone:

Gastric Inhibitory Peptide; 

Glucose-Dependent Insulinotropic Peptide

(GIP)

K cells of duodenum and jejunum

19

Stimulous for secretion of GI hormone:

Gastrin

(3)

  1. Proteins
  2. Distension
  3. Vagus

20

Stimulous for secretion of GI hormone:

Cholecystokinin (CCK)

(2)

  1. Protein 
  2. Fatty acids

21

Stimulous for secretion of GI hormone:

Secretin

(2)

  1. H+ in duodenum (acid)
  2. Fatty acids in duodenum

22

Stimulous for secretion of GI hormone:

Gastric Inhibitory Peptide; 

Glucose-Dependent Insulinotropic Peptide

(GIP)

(3)

  1. Fatty acids
  2. Protein
  3. Glucose

23

Action of GI hormone:

Gastrin 

(2)

  1. Stimulates gastric acid secretion
  2. Stimulates growth of gastric mucosa

24

Action of GI hormone:

Cholecystokinin (CCK)

(4)

  1. Increases pancreatic enzyme and HCO3- secretion
  2. Gallbladder contraction/relaxation of sphincter of Oddi
  3. Stimulates growth of exocrine pancreas/gallbladder
  4. Inhibits gastric emptying

25

Action of GI hormone:

Secretin

(2)

  1. Increases pancreatic and biliary HCO3- secretion
  2. Decreases gastric H+ secretion

26

Action of GI hormone:

Gastric Inhibitory Peptide;

Glucose-Dependent Insulinotropic Peptide (GIP)

(3)

  1. Increases insulin secretion
  2. Decreases gastric H+ secretion
  3. Inhibition of gastric emptying

27

Site of secretion of GI candicate hormone:

Motilin

Upper duodenum

28

Site of secretion of GI candicate hormone:

Pancreatic Polypeptide

Pancreas

29

Site of secretion of GI candicate hormone:

Enteroglucagon

Intestinal cells

30

Site of secretion of GI candicate hormone:

Glucagon-like Peptide I (GPL-1)

Intestinal L cells

31

Stimulous for secretion of GI candidate hormone:

Motilin

(1)

  1. Fasting state

32

Stimulous for secretion of GI candidate hormone:

Pancreatic Polypeptide

(3)

  1. Cholestrol
  2. Protein 
  3. Lipid ingestion

33

Stimulous for secretion of GI candidate hormone:

Enteroglucagon

(2)

  1. Fat
  2. Hypoglycemia

34

Stimulous for secretion of GI candidate hormone:

Glucagon-Like Peptide 1 (GLP-1)

(1)

 

  1. Hyperglycemia

35

Action of GI candidate hormone:

Motilin

(1)

  1. Stimulates myoelectric complex → induces vigorous GI peristalsis

36

Action of GI candidate hormone:

Pancreatic Polypeptide

(2)

  1. Decreases pancreatic enzyme secretion
  2. Decreases pancreatic HCO3- secretion

37

Action of GI candidate hormone:

Enteroglucagon

(1)

  1. Increases hepatic glyconeogenesis

38

Action of GI candidate hormone:

Glucagon-Like Peptide 1 (GLP-1)

(2)

  1. Increases insulin secretion from pancreatic beta-cells
  2. Decreases gastric emptying

39

Site of secretion of GI paracrine:

Somatostatin

(3)

D cells of:

  1. Stomach
  2. Duodenum
  3. Pancreas

40

Site of secretion of GI paracrine:

Histamine

(1)

 

  1. Mast cells of the gastric mucosa

41

Action of GI paracrine:

Somatostatin

(1)

  1. Inhibits all GI hormones (decreases acid secretion)

42

Action of GI paracrine:

Histamine

(1)

  1. Stimulates actid secretion directly and indirectly (buy potentiating the effects of gastrin and vagal stimulation)