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Flashcards in GI pharmacology Deck (31):
1

Examples of PPIs

Omeprazole and lanzoprezole

2

Where are proton pumps located

Apical membrane of parietal cells

3

Are PPIs activated in acid or alkali

Acid

4

5 uses of PPI

Peptic ulcer, GORD, dyspepsia, H.pylori and zollinger-ellison tumour

5

What drugs are used in the triple therapy for H.pylori

Omeprazole, clarithromycin and amoxacillin or omeprazole, clarithromycin and metronidiazole

6

Examples of H2 receptor antagonists

Ranitidine and famotidine

7

Where are H2 receptors located

Basolateral membrane of parietal cells

8

What cells secrete histamine

ECL

9

When are H2 antagonists used instead of PPIs

Pre-op

10

Examples of antimotility drugs

Loperamide and codeine phosphate

11

What receptors do antiomotility drugs act on

Opioid receptor

12

What are antimotility drugs effect on peristalsis and sphincters

Decrease peristalsis and constrict sphincters

13

When to use anti-motility drugs

Acute diarrhoea and diarrhoea in IBS

14

What disease do you not use antimotility drugs and why

UC due to possible toxic megacolon and perf

15

Examples of bulk forming laxatives (3)

Ispagula husk, methylcelluose and sterculia

16

When are bulk forming laxatives used

Constipation and faecal impaction

17

When not to use bulk forming laxatives

Possible obstruction/ileus

18

Why not use bulk forming laxatives after operations

Usually ileus

19

Examples of osmotic laxatives (4)

Lactulose, macrogols, citrate and phosphate enemas

20

What organ failure are osmotic laxitives useful in

Liver failure

21

Examples of stimulant laxatives (4)

Senna, bisocodyl, glycerol suppository and docusate sodium

22

Examples of H1 receptor antagonists (3)

Cyclizine, cinnarazine and promethazine

23

What do H1 receptor antagonists do

Block the H1 receptor in the vomiting centre and also block M1 receptors

24

When are H1 receptor antagonists used

Motion sickness, vertigo and post op

25

Side effects of H1 receptor antagonists

Drowsiness/sedation

26

When not to use H1 receptor antagonists

At risk of hepatic encephalopathy and prostatic hyperplasia

27

Examples of 5HT3 receptor antagonists (3)

Ondansetron, granisetron and palonosetron (setrons)

28

3 locations of 5HT3 receptor antagnoists

CTZ, NTS and peripherally on terminal of vagal afferent fibres innervating the GI tract

29

indications of 5HT3 receptor antagonists

Chemotherapy, radiotherapy and following general anaesthetic

30

What can 5HT3 receptors antagonists do to the heart

Prolong QT interval

31

Side effects of 5HT3 receptors antagonists

Constipation, diarrhoea and vomiting