Gilbert Syndrome

Question 1

Mneumonic for genetic causes of jaundice

Answer 1

U Can Go C DR

Unconjugated:
Crigler-Najjar syndrome
Gilbert syndrome

Conjugated:
Dubin-Johnson syndrome
Rotor syndrome

Question 2

Gilbert syndrome cause

Answer 2

Decrease in hepatic glucuronosyltransferase activity

Question 3

Gilbert syndrome presentation

Answer 3

Recurrent episodes of mild jaundice precipitated by stressors (surgery, illness, etc)

Question 4

Gilbert syndrome labs

Answer 4

Isolated unconjugated hyperbilirubinemia
(Normal liver enzymes and complete blood counts)