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Flashcards in glomerular disesases Deck (22):
1

Nephrotic vs nephritic

nephrOtic: predominant feature: proteinuria

Nephritic: proteinuria + RBC cast

2

Nephritic syndrome=Glomerulonephritis
characteristics

-Edema
-hematuria= determine if its glomerular vs nonglomerular
Dysmorphic RBC or *RBC cast**indication of glomerulonephritis

-proteinuria
-lipiduria
-renal failure can occur and can be rapidly progressive

3

what correlates with glomerular damage

and the severity of this can relate to progression of underlying renal disease

proteinuria

4

which glomerulnoephritis disease does not usually have renal biopsy performed? why not?

Asymptomatic hematuria

patient will have no kidney disease, no proteinuria

5

what are the 3 major finding on biopsy for asymptomatic hematuria

normal, thin basement membrane nephropathy, IgA nephropathy

6

mesangial cell proliferation indicates what?

IgA neuropathy

7

what is IgA nephropathy

asymptomatic hematuria with proteinuria

8

presence of cellular crescents indicates what?

other characteristics?

Rapidly progressive glomerulonephritis

proteinuria
hematuria
renal failure*
oliguria
edema
HTN

9

Main causes of rapidly progressive glomerulonephritis

direct immunoglobin attack

immune complex deposition

pauci-immune glomerulonephritis

10

which nephritic syndrome is considered a medical emergency

rapidly progressive glomerulonephritis

11

which has linear deposits of IgG and has continuous IgG ribbon like pattern?

Direct immunoglobulin attack

12

what is the most common acute glomerulnoephritis?
causes?

post-infectious glomerulonephritis: immune complex formation due to glomerular deposition of strep nephritiogenic antigens. could be due to strep/bacterial, viral, or parasitic.

13

what is pulmonary renal syndrome?

causes?

acute glomerular nephritis + pulmonary hemorrhage

cause:
-Anti-GBM (good pasture syndrome)
-systemic vasculitis (wegener syndrome)
-Lupus

14

which will have abscence of staining?

pauci-immune glomerulonephritis

15

what are the characteristics to nephrotic syndrome

MASSIVE proteinuria
hypoproteinemia/hypoalbuminemia
edema
hyperlipidemia
lipiduria (lipid cast in urine)

16

which will have granular pattern, more diffuse deposition in glomerulus

immune complex depsition

17

most common cause of nephrotic syndrome in children? adults?

children: minimal change disease

Membranous glomerulopathy: elderly
Focal segemental glomerulsclerosis: common in adults/AA

18

what will you see under electron-microscopy for minimal change disease? tx?

effacement of foot processes

IMMEDIATELY tx with steroids; dont biopsy

19

characteristics of membranous glomerulopathy?

thickening of basement membrane due to*** sub-epithelial deposits****

Spikes on basement membrane

effaced foot processes similar to minimal change disease

20

what is the marker for intraglomerular HTN an can also directly cause renal damage

proteinuria

21

Indication for percutaneous renal biopsy

-cause cannot be predicted with reasonable accuracy by less invasive procedure
-diff dx included disease that have diff tx or prognosis

-signs/symptoms suggest disease can be dx by pathologic evaluation

22

what is the gold standard for dx renal disease? when is it contraindicated

percutaneous renal biopsy

contraindicated in DIABETIC kidney disease