Glomerular Filtration Rate and Proteinuria Flashcards Preview

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Flashcards in Glomerular Filtration Rate and Proteinuria Deck (19):
1

How do you determine Qexcr in the kidney?

Qexcr = UFR x [urine]

2

How do you determine Qfilt in the kidney?

Qfilt = GFR x [serum]

3

If Qfilt = Qexcr, then GFR = ____________

{UFR x [urine]} / [serum]

4

How is creatinine produced and what makes it a good marker of GFR?

Creatinine is produced on a constant basis by metabolism of muscle creatine

It is freely filtered by the glomeruli and minimally secreted by the tubules

5

What are normal values for serum creatinine in...

Men:

Women:

Children:

Men: 0.9 to 1.3 mg/dl or 79 to 114 micromol/L

Women: 0.8 to 1 mg/dl or 70 to 88 micromol/L

Children: 0.5 to 1 mg/dl or 44 to 88 micromol/L

6

Creatinine clearance equation (assuming it is equal to GFR)

Cr cl = {UFR x [urine]} / [serum]

7

If GFR is impaired, how are creatinine levels in the urine maintained?

Increase serum creatinine levels compensate for decreased GFR

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8

What is the normal value for GFR?

100 ml/in or 150 liters/day

9

As stages of chronic kidney disease progress, GFR _______

decreases

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10

Dialysis is required in chronic kidney diseae when GFR is less than ________

10 ml/min

11

Serum creatinine and GFR have an _______ relationship

inverse

12

What factors are sometimes used in equations calculating GFR from creatinine?

Age, race, gender, body surface area

13

What is the Cockcroft-Gault formula?

Cr cl = [(140-age) x weight(kg)] / [72 x serum creatinine]

* multiply by 0.85 in women

14

How is proteinuria assessed in the lab

Negative or positive readings for protein by urine dipstick

15

What types of samples are used to quantify urine protein?

24 hour urine sample

"spot" urine sample (not as accurate)

16

How does proteinuria lead to edema?

Glomerular disease → glomerular protein leak overwhelms tubular re-absorbtion → Loss of albumin → low plasma oncotic pressure → edema

17

Urine protein more than 3 grams per day may cause ______ _______ with edema

nephrotic syndrome

18

In healthy individuals there are less than _____mg of protein in a 24 hour urine sample

150mg

19

How does proteinuria happen in the absence of kidney dysfunction?

Excess proteins can be produced in other parts of the body which will overwhelm the kidney's capacity to control levels