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Flashcards in Glucorticosteroids Deck (11)
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1

Describe the anti-inflammatory uses for glucocorticosteroids.  3

  1. IBS
  2. Inflammation
  3. Asthma

2

Describe the immunosuppressive uses for glucocorticosteroids. 6

  1. allergic reactions
  2. organ transplants
  3. cancer: haemotological
  4. autoimmunes
  5. rheumatic disorders
  6. skin disorders

3

Describe the other uses for glucocorticosteroids.  4

  1. adrenal insufficiency
  2. reduces respiratory distress by developing the lungs in premature neonates
  3. MS
  4. Renal disease

4

Describe the mechanism of action of glucocorticosteroids: 3

  1. Binds cytoplasmic glucocorticoid receptor
  2. Affects gene expression via glucocorticoid response elements (GREs)
  3. Results in either induction or inhibition of gene expression 

5

 susceptibility to infections and cancer results from: 2

 

  1.  decreased inflammatory response
  2. decreased immunological response

6

Fat depoists and diabets results from GS use causing: 4

  1.  increased liver glycogen deposits,
  2. increased gluconeogenesis
  3. increased glucose output from the liver
  4. decresed glucose utilization

7

Muscle wasting, growth suppression and osteoporosis/osteonecrosis result from: 2

  1. increased protein catabolism
  2. increased bone catabolism 

8

Psychosis and aggression results from

Changes in mood

9

Gastric ulceration results from

increased gastric acid and pepsin production

10

Na and H2O retention, hypertension and oedema, hypokalaemia and muscle weakness results from

  1. Increased Na reabsorption
  2. Increased K/H excretion

11