Glycolysis

Question 1

what is glycolysis (simple)
where does it occur?
how much ATP consumed to occur? how much does it produce?

Answer 1

• glycolysis: conversion of glucose to pyruvate.
• location: in the cytosol

- requires 2 ATP to occur, produces 4 ATP

Question 2

see mess slides - MET MESS PBL 4 !!

The important steps are:

• *•Glucose to Glucose-6-phosphate**
• G6P cannot leave the cell. Therefore, this process locks the molecule into the cell.
• Via the enzymes glucokinase or hexokinase (in muscle tissue)

•Fructose-6-phosphate to Fructose-1,6-bisphosphate
•Via the highly regulated Phosphofructokinase-1 (PFK-1)
1.High ATP:AMP ratio -> Decreased PFK activity
2.High citrate -> Decreased PFK activity
3.High Fructose-2,6-bisphosphate -> Increased PFK activity

Question 3

glycolysis only extracts WHAT % of potential energy from glucose. How does this differ to TCA / Krebs?

Answer 3

• glycolysis only extracts 5% of potential energy from glucose.
• TCA / Krebs used to produced NADH & FADH