Glycopeptides Flashcards
1
Q
What is the spectrum of coverage of vancomycin?
A
Mostly gram-positive bacteria
2
Q
What is the route of administration of vancomycin?
A
Mainly IV
Only exception is CDAD with PO vancomycin
3
Q
How is vancomycin excreted?
A
Renal clearance
4
Q
When is vancomycin given as prophylaxis?
A
In pneumonia where MRSA is expected and meningitis caused by penicillinase-resistant S. pneumoniae
5
Q
What are the 3 adverse reactions caused by vancomycin?
A
- Thrombophlebitis with fever & chills
- Red-neck syndrome
- Nephrotoxicity & ototoxicity
6
Q
What is vancomycin pregnancy rating?
A
- Cat C for parental formulations
- Cat B for oral capsules
7
Q
What is the mechanism of action of vancomycin?
A
Vancomycin interferes with the transglycosylation of the cell wall precursor units, hence inhibiting bacterial cell wall synthesis
