Gonadal Hormones and Inhibitors Flashcards Preview

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Flashcards in Gonadal Hormones and Inhibitors Deck (34)
1

Ethinyl estradiol increases the risk of what cancers?

Endometrial and breast ca

2

What drug will you combine with ethinyl estradiol to prevent endometrial and breast ca?

Progestin

3

Used for postmenopausal hormonal replacement therapy and intractable dysmenorrhea

Ethinyl estradiol

4

Used for atrophic vaginitis

Diethylstilbestrol

5

Causes clear cell vaginal adenocarcinoma in daughters of mother who takes this drug

Diethylstilbestrol

6

Used in assisted reproduction and anovulation induction

Progestins: Norgestrel

7

Causes decreased HDL and weight gain

Norgestrel

8

Appetite stimulant

Megestrol

9

Type of oral contraceptive which closely mimics normal menses

Biphasic or triphasic

10

The primary action of combination hormonal contraceptives

Inhibition of ovulation

11

Emergency contraception

Levonorgestrel

12

Selective estrogen receptor modulator used for hormone-responsive breast ca; causes endometrial hyperplasia and endometrial ca

Tamoxifen
Toromifene

13

SERM that is used for osteoporosis and breast cancer prevention; does not cause endometrial ca

Raloxifene

14

SERM that is used for induction of ovulation; causes ovarian enlargement and multiple pregnancies

Clomiphene

15

Estrogen synthesis inhibitor that is used for the management of breast cancers that are resistant to tamoxifen and for precocious puberty

Anastrozole (aromatase inhibitor)

16

Used for endometriosis

Danazol (weak cytochrome P450 inhibitor and partial agonist of progestin and androgen receptors);

Medroxyprogesterone acetate by intramuscular injection

17

Used for medical abortion and Cushing syndrome

Mifepristone
(Glucocorticoid- and progesterone-receptor antagonist)

18

Used to treat breast cancer that is resistant to first-line antiestrogen therapy

Fulvestrant (estrogen receptor antagonist in all tissues)

19

Androgen antagonist that is used for prostate ca

Flutamide

20

Androgen antagonist that is used for surgical castration

Nilutamide

21

Androgen antagonist that decreases sexual drive in men

Cyproterone

22

5-alpha reductase inhibitor used for the treatment of BPH, male-pattern baldness, and hirsutism

Finasteride

23

Major ovarian estrogen in women

Estradiol

24

Example of estrogens

Ethinyl estradiol
Mestranol
Estrogen esters

25

Example of progestins

Norgestrel
Medroxyprogesterone acetate
Megestrol acetate

26

Example of SERMs

Tamoxifen
Toremifene
Raloxifene
Clomiphene

27

Side effect of SERMs

Hot flushes
Thromboembolism
Endometrial hyperplasia

28

SERM used for osteoporosis

Raloxifene

29

SERM used for ovulation induction

Clomiphene

30

GnRH agonist

Leuprolide

31

GnRH receptor antagonist

Ganirelix
Cetrorelix

32

Used in combination with misoprostol for medical abortion

Mifepristone (progestin and glucocorticoid receptor antagonist)

33

An antifungal drug which inhibits gonadal and adrenal steroid synthesis; used to suppress adrenal steroid synthesis in patients with steroid-responsive metastatic prostate cancer

Ketoconazole

34

Men who use large doses of anabolic steroids are at increased risk of?

Cholestatic jaundice and elevation of aspartate transaminase levels in the blood