Gonads Flashcards Preview

128 - Gen Endocrine > Gonads > Flashcards

Flashcards in Gonads Deck (12):
1

What is the male hypothalamic-pituatry-gonadal axis?

A image thumb
2

What do leydig cells do?

Make testosterone

3

What do sertoli cells do?

Make ABG to keep sperm in the testicles and inhibin

Stop the growth of mullerian ducts

 

 

4

What is the female hypothalamic-pituatry-gonadal axis?

A image thumb
5

What are the symptoms, investigations, pathology and treatment of male primary hypogonadism?

 

 

Symptoms - baldness, loss of libido, small or absent testicles, gynacoemastia, infertility

Investigations - High GNRH, HIGH LH/FSH, Low Testosterone

Treatment - Testosterone

Examples - Chemo, undescended testicles, Klinefelter 47XXY

6

What are the symptoms, investigations and pathology of male secondary hypogonadism?

 

Pathology - This is a problem with the stimulation of the gonads. Eg a pituatry tumour,  diabetes

 

Symptoms - baldness, loss of libido, small or absent testicles, gynacoemastia, infertility

Investigations - Low GNRH, LOW LH/FSH, Low testosterone

 

7

What are the symptoms, pathology, investigations and treatment of foetal androgen insufficiency?

 

Symptoms - A women with infertility, amenorrhea

Investigations - High testosterone, XY karyotype

Pathology - This is a resistance to androgens in the womb making a man have female characteristics

Treatment - Surgery, testosterone

8

What are the symptoms, pathology, investigations and treatment of PCOS

 

Symptoms - Amenorrhea, acne, virulence, infertility

Investigations - HIGH androgen, High FSH:LH ratio

Pathology - This is confirmed via US and is linked to diabetes

Treatment - Oestrogen and infertility treatment

9

What are the symptoms, pathology, investigations and treatment of ovarian tumour?

 

Symptoms - Weight Loss, amenorrhea, hirsutism

Investigations - High testosterone, CA125

Confirmed via US/CT

Treatment - Treat the cancer

10

What are the symptoms, pathology, investigations and treatment of Turners

 

Symptoms - Webbing, short, lymphodeama of hands and feet

Investigations - High FH/LSH, Low oestrogen, Low GH

Pathology - 46 XOnly one female chromosome

Treatment - Oestrogen or GH if young

11

What are the symptoms, pathology, investigations and treatment of precocious puberty

 

Symptoms - Early menarche

Investigations - High GNRH, LH/FSH, oestrogen for her age

Treatment - LNRH/GNRH analogues for negative feedback

12

What are the symptoms, pathology, investigations and treatment of premature ovarian failure

 

Symptoms - amennorhea before 40 for 6 months, hot flushes, low libido

Investigations - HIGH FSH x2

 

Treatment - Ovum replacement, Oestrogen