GonorrheaInfections Flashcards Preview

Micro Exam VI > GonorrheaInfections > Flashcards

Flashcards in GonorrheaInfections Deck (21):
1

**General Features of Neisseria:

Gram (-) diplococci (KIDNEY BEAN SHAPE). Aerobic. FREE LIVING. NO CAPSULE

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**Appearance of Neisseria:

Kidney bean

3

**Test results for Neisseria:

**Gram (-) kidney bean shaped in neutrophils. Oxidase (+) Catalase (+)**

4

**How to differentiate between N. Gonorrhoeae and N. Meningitidis:

N. Meningitidis FERMENTS MALTOSE. N. Gonorrhoeae does NOT. Meningitidis HAS A CAPSULE.

5

**Virulence Factors of N. Gonorrhoeae (6):

Pilin. Porin. Opacity Protein. LOS. IgA Protease. Beta-lactamase

6

Which virulence factors of N. Gonorrhoeae undergo antigenic variation to avoid immune response (4):

Pilin. Porin. Opacity Protein. LOS

7

Biologic Effect of Pilin in N. Gonorrhoeae:

Attachment, anti-phagocytic

8

Biologic effect of Porin in N. Gonorrhoeae

Promotes intracellular survival

9

Biologic effect of Opacity Protein in N. Gonorrhoeae

Attachment to eukaryotic cells

10

Biologic Effect of LOS in N. Gonorrhoeae

ENDOTOXIN.

11

LOS Variation:

Can change its appearance to escape immune response.

12

N. Gonorrhoeae infection is most common in:

African Americans. people 15-24. SE US

13

**Higher risk of disseminated N. Gonorrhoeae disease in:

patients with deficiencies in the latter part of the complement system (C5-C9=MAC)

14

Pathogenesis of N. Gonorrhoeae:

Attachment (Pili, PorB, Opa) > penetrate into cell and multiply > pass through cells to **sub epithelial space where infection is ESTABLISHED** LOS stimulates inflammation > SYMPTOMS.

15

**Symptoms of N. Gonorrhoeae infection:

Mucopurulent discharge and dysuria. **95% of infected men** will have symptoms. 50% of women will not.

16

Leading cause of Purulent Arthritis in Adults:

Disseminated infection of N. Gonorrhoeae

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**Presentation of Disseminated N. Gonorrhoeae:

Septicemia Infection of skin + joints= Swelling and redness in wrists, knees and ankles. Rash over extremities

18

N. Gonorrhoeae disease beyond UG:

Purulent Conjunctivitis (Opthalmia Neonatorum) Anorectal gonorrhea. Pharyngitis

19

Opthalmia Neonatorum:

Purulent ocular infection particularly common in newborns during vaginal delivery. Caused by N. Gonorrhoeae.

20

**Diagnosis of N. Gonorrhoeae:

Direct smear of discharge: **Gram (-), bean shaped diplococci IN NEUTROPHILS** Can also use NAAT from urine/discharge, also.

21

Treatment of N. Gonorrhoeae:

Ceftriaxone PLUS doxycycline or azithromycin to treat chlamydia (presumed with gonorrhea)