GPHT LEC - Inflammation Flashcards Preview

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Flashcards in GPHT LEC - Inflammation Deck (75):
1

A complex reaction to various injurious agents

Inflammation

2

 Consists of vascular responses, migration and activation of leukocytes, and systemic reactions

Inflammation

3

Unique features of inflammation

◦ Reaction of blood vessels
◦ Accumulation of fluids and electrolytes in extravascular space

4

components of inflammatory response

vascular and cellular rxn

5

vascular rxn composed of

vasodilation
increased permeability

6

cellular rxn composed of

 Margination
 Rolling
 Adhesion
 Transmigration
 Migration

7

Inflammation is terminated when

the inciting agent is eliminated and the mediators have degenerated.

8

A rapid response to an injurious agent that aims to rapidly bring mediators of inflammation to the site of injury

acute inflammation

9

characteristics of acute inflammation

◦ Alterations in blood flow
◦ Increased vascular permeability
◦ Emigration,accumulation,and activation of neutrophils

10

distinctive feature of acute inflammation

Infiltration by polymorphonuclear cells (neutrophils, eosinophils, basophils)

11

Hallmark of acute inflammation:

◦ Increased vascular
permeability

12

Refers to an excess fluid in the interstitial tissue or serous cavities

edema

13


The escape of fluid, proteins, and blood cells from the vascular system into interstitial tissue or body cavities
Two types
◦ ◦
 
Exudate Transudate

exudation

14

two types of exudate
high cellularity, sp gr and protein

exudate

15

two types of exudate
low to none cellularity, sp gr and protein

transudate

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An exudate rich in inflammatory cells (leukocytes) and cellular debris

pus

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morphologic patterns of acute inflammation

◦ Plasma-like effusion with no cells


Serous

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morphologic patterns of acute inflammation
◦ There is abundant protein- rich fluid exudate with a relatively low cellular content

Serous

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morphologic patterns of acute inflammation
◦ Early inflammation,heart failure, pleural effusions

Serous

20

morphologic patterns of acute inflammation
◦ Inflammation of the serous
cavities, such as peritonitis, and inflammation of a synovial joint, acute synovitis


Serous

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morphologic patterns of acute inflammation
◦ Vascular dilatation may be apparent to the naked eye

Serous

22

morphologic patterns of acute inflammation
◦ Contains dying and degenerate neutrophils,proteins,tissue debris, infecting organisms

Serous

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morphologic patterns of acute inflammation
◦ The pus may become walled-off by granulation tissue or fibrous
tissue to produce an abscess (a localized collection of pus in a tissue)

Serous

24

morphologic patterns of acute inflammation
◦ Caused by pyogenic bacteria

Serous

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(a localized collection of pus in a tissue)

abscess

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If a hollow viscus fills with pus,this is called an

empyema,

27

accumulation of fluid in body cavities

effusion

28

morphologic patterns of acute inflammation
Contains large amounts of fibrinogen

fibrinous

29

morphologic patterns of acute inflammation
◦ Forms thick, sticky meshwork that may cause areas to stick
together

fibrinous

30

morphologic patterns of acute inflammation
◦ Often seen in acute pericarditis giving the parietal and visceral
pericardium a 'bread and butter' appearance.

fibrinous

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morphologic patterns of acute inflammation
◦ Thick fibrin coating

fibrinous

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morphologic patterns of acute inflammation
◦ Contains fibrinous or fibrinopurulent material with necrotic cells

Membranous

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morphologic patterns of acute inflammation
◦ Contains both serous and hemorrhagic materials

Serosanguinous

34

morphologic patterns of acute inflammation
◦ Often found in mucous membranes, some microbial infection

Membranous

35

morphologic patterns of acute inflammation
◦ Caused by bleeding, serous exudation like injury and burns

Serosanguinous

36

Exudates in Inflammatory Processes
Contains large amount of RBCs and other cells

Hemorrhagic

37

Exudates in Inflammatory Processes
◦ Damaged or vascular injury or permeable blood vessels or depletion of
coagulation factors

Hemorrhagic

38

Exudates in Inflammatory Processes
◦ Acute pancreatitis due to proteolytic destruction of vascular walls, and
in meningococcal septicemia due to disseminated intravascular coagulation

Hemorrhagic

39

Exudates in Inflammatory Processes
◦ Contains large amount of mucous and epithelial cells

Mucinous or Catarrhal

40

Exudates in Inflammatory Processes
◦ When mucus hypersecretion accompanies acute inflammation of a mucous membrane

Mucinous or Catarrhal

41

Exudates in Inflammatory Processes
◦ Inflammatory conditions like allergic rhinitis,common

Mucinous or Catarrhal

42

Types of Inflammation According to Location
Localized collection of pus in a part of the body, surrounded by an inflamed area

abscess

43

Types of Inflammation According to Location
The area will most likely look like a giant boil or cyst that can become extremely red and infected

abscess

44

Types of Inflammation According to Location
An open sore of the skin, eyes or mucous membrane, often caused by an initial abrasion and generally maintained by an inflammation and/or an infection

ulcer

45

Types of Inflammation According to Location
Mucosal surface
Thick mucous and white blood cells

catarrhal

46

Types of Inflammation According to Location
Formed by the fibrin and necrotic surface epithelium

pseudomembranous

47

Types of Inflammation According to Location
A structure which resembles the luminal surface of the tissue (looks like the affected tissue is covered by a membrane)

pseudomembranous

48

Types of Inflammation According to Location
 An epithelium becomes coated by fibrin, desquamated epithelial cells and inflammatory cells

membranous

49

Types of Inflammation According to Location
An example is the grey membrane seen in pharyngitis or laryngitis due to Corynebaeterium diphtheriae

membranous

50

mononuclear cells in chronic inflammation

plasma cells, macrophages, lymphocytes

51

slimy film covering
what morphologic pattern of acute inflam

membranous

52

what morphologic pattern of acute inflam
in cancers, trauma, lungs

serosanguinous

53

what morphologic pattern of acute inflam
bloody but not as viscous as blood

serosanguinous

54

what morphologic pattern of acute inflam
diluted pink hemorrhagic material

serosanguinous

55

mucinous exudates common in organs like

organs of RT and GT

56

prototype of hemorrhagic exudate

acute pancreatitis

57

common exudate, encountered by many

mucinous or catarrhal

58

most frequent cause of abscess

bacteria

59

what type of inflammation accdg to location/appearance
acute appendicitis

abscess

60

what type of inflammation accdg to location/appearance
found in nose and GIT

catarrhal

61

what type of inflammation accdg to location/appearance
found in GIT

pseudomembranous

62

extensive deposition of collagen

hypertrophic scar

63

CT replacement accomplished by two processes

angiogenesis and fibrosis

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haphazard activity of reparative cells

cheloid

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cells predominant in acute

neut

66

cells predominant in chronic

lympho

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nucleoli in granuloma

horseshoe

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formation of the mature scar

cicatrization

69

Type of inflam according to extent
Interstitial pneumonia

Diffuse

70

Sarcoidosis type of inflammationo

Granulomatous inflammation

71

No discernible granule type of granulomatous inflammation

Immune granuloma

72

Type of replacement by a CT scar
Reorganization of the fibrous tissue, contraction of wound edges

Remodeling

73

Fibrinous inflammation may lead to

Scarring

74

Central region of abscess

Necrotic leukocytes and tissue cells

75

less vascular, pale, contracting tissue

cicatrix

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