Flashcards in Gproteins and function Deck (13)
What is the function of gproteins?
Transduce a extracellular signal into intracellular response
involved in signaling
membrane vesicular transport
What are the classes of Gproteins?
II-small monomeric G protiens
What is the function of a subunit of class I g protiens?
binding & hydrolyzing
interact with receptor and effector proteins
it has GTPase activity
What is the fuction of the bg subunit of class II g protiens?
they are hydrophobic
What family does class II gproteins belong?
Ras superfamily of small gprotiens
they psses GTPase activity
cycles through GDP/GTP exchange
What are targets for G protiens?
Adenylyle cyclases- 9 types
Guanylyl cyclases (membrane bound type 1; Soluble type 2)
Phospholipase C (PLC) (13 types)
Phospholipase A (A1 and A2)
What secondfary messengers does gprotiens produce?
What are third messengers produced by g protiens?
What is Gs?
stimulatory g protein
if activates adenylate cyclase
What is Gi?
inhibitory g protein?
inhibits adenylate cyclase
What modulates G protiens?
regulator G protein signaling (RGS)
GTPase activating proteins (GAPS)
GTPase inhibitory proteins
What is the function of GAPs?
GTPase activating protein
they inhibit G protein function by promotes GTPase activity of alpha subunit