Group 1 - Morphine Sulfate

Question 1

Morphine Sulfate

Drug Class?

Answer 1

Morphine Sulfate Drug Class:

Narcotic agonist

Question 2

Morphine Sulfate

Mechanism of Action (MOA)?

Answer 2

Morphine Sulfate MOA:

• Elevates pain threshold by acting on the pain receptors in the brain.
• Depresses CNS, depresses brainstem respiratory centers.
• Increases venous capacitance, vasodialates arterioles, reducing preload and afterload.
• Histamine release.

Question 3

Morphine Sulfate

Indications?

Answer 3

Morphine Sulfate Indications:

• Analgesia
• Pulmonary edema (Cardiogenic)

Question 4

Morphine Sulfate

Contraindications?

Answer 4

Morphine Sulfate Contraindications:

• Respiratory depression
• Head injuries
• Elevated intracranial pressure
• Asthma (relative)
• Abdominal pain (relative)

Question 5

Morphine Sulfate

Adverse Reactions?

Answer 5

Morphine Sulfate Adverse Reactions:

• CV: Brady/Tachy-dysrhythmias; orthostatic hypotension
• Resp: Respiratory depression or arrest
• CNS: Excess sedation, seizures, pupillary constriction
• Derm: Histamine release may cause local urticaria

Question 6

Morphine Sulfate

Adult Dose?

Answer 6

Morphine Sulfate Adult Dose:

• 1 - 3 mg increments slow IV push (over 1 - 5 minutes) until desired effect

Question 7

Morphine Sulfate

Pediatric Dose?

Answer 7

Morphine Sulfate Pediatric Dose:

• 0.1 - 0.2 mg/kg slow IV push

Question 8

Morphine Sulfate

Onset of Action?

Answer 8

Morphine Sulfate Onset of Action:

Seconds

Question 9

Morphine Sulfate

Peak Effects?

Answer 9

Morphine Sulfate

Peak Effects: 20 minutes

Question 10

Morphine Sulfate

Duration of Action?

Answer 10

Morphine Sulfate

Duration of Action: 2 to 4 hours

Question 11

Morphine Sulfate

AZ Drug Box Minimum Supply?

Answer 11

Morphine Sulfate

AZ Drug Box Minimum Supply: 20 mg