Flashcards in Haematology Deck (11):
When is it reasonable to consider a blood transfusion?
Hb < 8, especially with symptoms
What blood will be transfused in the following case:
A large epistaxis which has settled over the last 30 mins with conservative management. Patient light headed and nauseous. Hb 7.1
IV packed red blood cells
What is the mechanism of action of aspirin?
What is the mechanism of action of clopidogrel?
Antagonises adenosine diphosphate receptors on platelets
What is the mechanism of action of warfarin?
Inhibits vitamin K epoxide reductase, preventing carboxylation of vitamin K dependent factors
What are the vitamin K dependent factors?
II, VII, IX, X
What is rouleaux formation?
Red cells will appear stacked like a set of coins
Can be found in reactive process due to acute phase proteins or in plasma cell dyscrasias due to paraproteins
What is not an appropriate action in a patient on warfarin presenting with haematemesis and hypotension?
Giving fresh frozen plasma
Does not give sufficient coagulation correction
Diagnosis: 18 y/o male, 8 week enlarging lump in neck, night seats, axially lymphadenopathy
Which investigation is most likely to give a definitive diagnosis of Hodgkins Disease?
Lymph node biopsy