Flashcards in Haematopoiesis Deck (19):
What are all blood cells derived from?
Haematopoietic stem cells (hemocytoblasts)
What are platelets? What do they play a role in?
How long do RBCs circulate in the body for?
In what 3 parts of the body are there notable haematopoietic sites?
Liver, spleen and bone marrow
Give two adaptations of RBCs to their function.
1) Biconcave shape, lipid bilayer --> flexible through capillaries
2) No organelles/nucleus, maximum space for Hb
What is the composition of blood in percentage terms?
(Less than 1% is leukocytes/platelets)
Name 5 leukocytes (WBCs)
When is a monocyte a macrophage?
When it is in the tissues and not the blood
Which WBCs are the first line killers of the innate immune system?
What do NK cells do?
Kill cells, by stimulating them to perform apoptosis
How do platelets help in clot formation?
They act as the initial primary plug and as a surface for clotting factors to make the final fibrin clot
How can blood cells be assessed?
Full blood counts
What is the term given to a particularly high RBC count?
What is the term given to a particularly high WBC count?
What is the term given to a particularly high platelet count?
What is the term given to a particularly low RBC count?
What is the term given to a particularly low WBC count?
What is the term given to a particularly low platelet count?