Haematopoiesis Flashcards Preview

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Flashcards in Haematopoiesis Deck (19)
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1
Q

What are all blood cells derived from?

A

Haematopoietic stem cells (hemocytoblasts)

2
Q

What are platelets? What do they play a role in?

A

Cell fragments

Clot formation

3
Q

How long do RBCs circulate in the body for?

A

120 days

4
Q

In what 3 parts of the body are there notable haematopoietic sites?

A

Liver, spleen and bone marrow

5
Q

Give two adaptations of RBCs to their function.

A

1) Biconcave shape, lipid bilayer –> flexible through capillaries
2) No organelles/nucleus, maximum space for Hb

6
Q

What is the composition of blood in percentage terms?

A

55% plasma
45% RBCs
(Less than 1% is leukocytes/platelets)

7
Q

Name 5 leukocytes (WBCs)

A
Basophils
Eosinophils 
Monocytes (Macrophages)
Neutrophils
Lymphocytes
8
Q

When is a monocyte a macrophage?

A

When it is in the tissues and not the blood

9
Q

Which WBCs are the first line killers of the innate immune system?

A

Eosinophils
Neutrophils
Basophils
Monocytes/macrophages

10
Q

What do NK cells do?

A

Kill cells, by stimulating them to perform apoptosis

11
Q

How do platelets help in clot formation?

A

They act as the initial primary plug and as a surface for clotting factors to make the final fibrin clot

12
Q

How can blood cells be assessed?

A

Full blood counts

Blood films

13
Q

What is the term given to a particularly high RBC count?

A

Polycythemia

14
Q

What is the term given to a particularly high WBC count?

A

Leukaemia

15
Q

What is the term given to a particularly high platelet count?

A

Thrombocythemia

16
Q

What is the term given to a particularly low RBC count?

A

Anaemia

17
Q

What is the term given to a particularly low WBC count?

A

Leukopenia

18
Q

What is the term given to a particularly low platelet count?

A

Thrombocytopenia

19
Q

What is the term given to a reduction in RBC, WBC and platelet levels?

A

Pancytopenia