Haematopoiesis Flashcards Preview

Body Logistics > Haematopoiesis > Flashcards

Flashcards in Haematopoiesis Deck (19):
1

What are all blood cells derived from?

Haematopoietic stem cells (hemocytoblasts)

2

What are platelets? What do they play a role in?

Cell fragments

Clot formation

3

How long do RBCs circulate in the body for?

120 days

4

In what 3 parts of the body are there notable haematopoietic sites?

Liver, spleen and bone marrow

5

Give two adaptations of RBCs to their function.

1) Biconcave shape, lipid bilayer --> flexible through capillaries
2) No organelles/nucleus, maximum space for Hb

6

What is the composition of blood in percentage terms?

55% plasma
45% RBCs
(Less than 1% is leukocytes/platelets)

7

Name 5 leukocytes (WBCs)

Basophils
Eosinophils
Monocytes (Macrophages)
Neutrophils
Lymphocytes

8

When is a monocyte a macrophage?

When it is in the tissues and not the blood

9

Which WBCs are the first line killers of the innate immune system?

Eosinophils
Neutrophils
Basophils
Monocytes/macrophages

10

What do NK cells do?

Kill cells, by stimulating them to perform apoptosis

11

How do platelets help in clot formation?

They act as the initial primary plug and as a surface for clotting factors to make the final fibrin clot

12

How can blood cells be assessed?

Full blood counts
Blood films

13

What is the term given to a particularly high RBC count?

Polycythemia

14

What is the term given to a particularly high WBC count?

Leukaemia

15

What is the term given to a particularly high platelet count?

Thrombocythemia

16

What is the term given to a particularly low RBC count?

Anaemia

17

What is the term given to a particularly low WBC count?

Leukopenia

18

What is the term given to a particularly low platelet count?

Thrombocytopenia

19

What is the term given to a reduction in RBC, WBC and platelet levels?

Pancytopenia