Haematopoiesis & Anaemia Flashcards Preview

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Flashcards in Haematopoiesis & Anaemia Deck (21):
1

What is haematopoiesis?

The formation of blood cells and platelets occurring in the bone marrow

2

What is the life span of an erythrocyte?

120 day half life

3

What is the life span of a neutrophil?

9-10 hours

4

What is the life span of a platelet?

4-5 days

5

Which is longer lived, a plasma B cell or a memory B cell?

Memory B Cell

6

In which type of bone can red marrow generally be found?

Flat bone

7

What is the main source of haematopoietic stem cells before birth?

The liver

8

What is the main source of haematopoietic stem cells at birth?

Long bones

9

What is the main source of haematopoietic stem cells after birth?

Flat bones

10

What is meant by the term, 'erythropoiesis'?

The formation of RBCs occurring in the bone marrow

11

List the stages in RBC production from erythroblast to mature RBC.

Erythroblast proliferates and matures (including shrinkage) to form reticulocytes, which then lose their nuclei to form erythrocytes/mature RBCs

12

What type of genetic information is stored in reticulocytes?

RNA

13

What does erythropoietin do and how does it do it?

Stimulates manufacture of erythrocytes via fibroblasts producing a glycoprotein hormone in the kidney, which then cooperates with growth factors to develop RBC precursors (erythroblasts --> reticulocytes)

14

What can a loss in erythropoietin (EPO) cause?

Anaemia

15

What can an excess of erythropoietin (EPO) cause?

Polycythaemia (too many RBCs)

16

Describe the negative feedback loop that involves EPO and haemoglobin (Hb).

If Hb decreases (e.g. in anaemia), EPO increases to compensate. However, it is worth noting that in renal insufficiency/failure, EPO cannot be produced

17

List the stages of granulopoiesis.

Myeloblast --> Promyeloblast --> Myelocyte --> Metomyelocyte --> Band cell --> Granulocyte

18

How long do the mitotic and post-mitotic stages of granulopoiesis respectively, last?

7.5 days
6.5 days

19

How frequent are stem cells in bone marrow (1 in …)?

1 in 1000-10000

20

Does red or yellow bone marrow increase with age?

Yellow

21

What is the precursor of a platelet?

A megakaryocyte