Flashcards in Haematopoiesis & Anaemia Deck (21):
What is haematopoiesis?
The formation of blood cells and platelets occurring in the bone marrow
What is the life span of an erythrocyte?
120 day half life
What is the life span of a neutrophil?
What is the life span of a platelet?
Which is longer lived, a plasma B cell or a memory B cell?
Memory B Cell
In which type of bone can red marrow generally be found?
What is the main source of haematopoietic stem cells before birth?
What is the main source of haematopoietic stem cells at birth?
What is the main source of haematopoietic stem cells after birth?
What is meant by the term, 'erythropoiesis'?
The formation of RBCs occurring in the bone marrow
List the stages in RBC production from erythroblast to mature RBC.
Erythroblast proliferates and matures (including shrinkage) to form reticulocytes, which then lose their nuclei to form erythrocytes/mature RBCs
What type of genetic information is stored in reticulocytes?
What does erythropoietin do and how does it do it?
Stimulates manufacture of erythrocytes via fibroblasts producing a glycoprotein hormone in the kidney, which then cooperates with growth factors to develop RBC precursors (erythroblasts --> reticulocytes)
What can a loss in erythropoietin (EPO) cause?
What can an excess of erythropoietin (EPO) cause?
Polycythaemia (too many RBCs)
Describe the negative feedback loop that involves EPO and haemoglobin (Hb).
If Hb decreases (e.g. in anaemia), EPO increases to compensate. However, it is worth noting that in renal insufficiency/failure, EPO cannot be produced
List the stages of granulopoiesis.
Myeloblast --> Promyeloblast --> Myelocyte --> Metomyelocyte --> Band cell --> Granulocyte
How long do the mitotic and post-mitotic stages of granulopoiesis respectively, last?
How frequent are stem cells in bone marrow (1 in …)?
1 in 1000-10000
Does red or yellow bone marrow increase with age?