Haemostasis Disorder

Question 1

What is abnormal bleeding

Answer 1

1. Lack of specific factor perhaps due to congenital and acquired or increased consumption/ clearance
2. Derivative function of a specific factor > genetic defect or acquired defect -drugs, synthetic defect, inhibition

Question 2

Describe the effect of thrombocytopenia

Answer 2

Bone marrow failure eg leukaemia, B12 deficiency, accumulated clearance eg immune and DIC (not enough platlets)

Thrombocytopenia: antibodies that develop against the platlets and binding of these antibodies means that they are cleared rapidly by the macrophages.

Mechanisms: failure of platlet production,shortened half life, increased pooling (hyper spleenism)

Question 3

Describe glycoproteins receptor deficiency

Answer 3

Absence of 2b - glanzanns

Absence of 1b - Bernard soulier

Question 4

Describe VWF disease

Answer 4

Normally hereditary and cause look at slide

Question 5

What is the test for disorders of primary haemostasis

Answer 5

Measure platlet count, platlet morphology, bleeding time and assay VWF

Question 6

Discuss haemophilia and disorders of coagulation

Answer 6

Look at slide

Question 7

Describe the rest of the notes

Answer 7

Notes