Flashcards in Haemotology - Coagulation & Consolidation Deck (9)
What type of deficiency should you suspect is a mixing study corrects an isolated prolonged clotting time?
A factor deficiency
Are a strong bleeding history and normal test results more likely to be a result of abnormalities in primary or secondary haemostasis?
If a patient has a normal APTT/PT, is a severe deficiency in secondary haemostasis likely?
If a patient has a normal platelet count, could you have an abnormality in primary haemostasis?
Yes - there could be a functional platelet abnormality
What does Willebrand's disease affect?
The body's ability to clot - time to clot is lengthened because of a deficiency in the von Willebrand factor
What could elevated INR and APTT be a result of?
A deficiency in clotting factors in both the intrinsic and extrinsic pathways
If fibrinogen looks low on the functional assay, but is slightly high in a total fibrinogen assay, what does this suggest?
Functionally abnormal fibrinogen
What would the effects of a Vit K inhibitor have on prothrombin time?
Would prolong prothrombin time, as Vit K inhibition would cause a deficiency in clotting factors 2, 7, 9 and 10