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Flashcards in handout 1 Deck (36):
1

cholinergic agonists PNS heart

M: decrease HR (SA node)
M: decrease contractility (atria only)
M: decrease conduction (AV node)

2

cholinergic agonists PNS blood vessels

M: (vasodilation)

(not innervated)

3

cholinergic agonists PNS BP

M: (decrease BP)

adverse effects: hypotension

4

cholinergic agonists PNS eye

M: miosis (contriction)
M: accommodation (near vision)
M: increase aquous humor outflow [glaucoma]--used clinically for glaucoma

5

cholinergic agonists PNS lung

M:
adverse effects: bronchoconstriction,
increase secretions

6

cholinergic agonists PNS GI/GU

M: increase salivation
[used clinically for xerostomia]

M: increase detrusor contraction
[used clinically to increase urinary flow]

M: increase motility [used clinically to paralytic ileus]
adverse effects: diarrhea

7

cholinergic agonists PNS
NMJ

Nm: muscle contraction
[used clinically for myastenia gravis]

8

cholinergic agonists PNS
CNS

M: memory/cognition/movement
[Alzheimer's disease]

9

cholinergic (PNS) antagonist
heart

increase HR
[used clinically for bradycardia]

10

cholinergic (PNS) antagonist
blood vessel

no cholinergic tone to antagonize

11

cholinergic (PNS) antagonist
BP

generally minimal effect

12

cholinergic (PNS) antagonist
Lung

bronchodilation [used clinically for asthma]

adverse effect: increased drying

13

cholinergic (PNS) antagonist
eye

1. bronchodilation [used clinically for asthma]
2. adverse effect: blurred vision
3. averse effect: decreased out flow
4. increased IOP
5. exacerbates glaucoma

14

cholinergic (PNS) antagonist
GI/GU

1. decreased salivation [create dry field]
--dry mouth
2. block detrusor [used clinically for overactive bladder]
--urinary hesitancy--retention
3. decreased GI motility [used clinically for diarrhea]
--constipation

15

cholinergic (PNS) antagonist
NMJ

1. flaccid paralysis
2. used in surgery as muscle relaxation

16

cholinergic (PNS) antagonist
CNS

1. used in parkinson'd disease and anti-emetic
2. side effects: sedation/confusion

17

adrenergic (SNS) agonists
heart

B1:
1. increased HR/increased contractility
2. used clinically for cardiogenic shock
3. SE: pro-arrhthmic, precipitate

18

adrenergic (SNS) agonists
blood vessels

a1:
1. vasoconstriction--SE: hypertension
2. used clinically for hypotensive shock and decongestant

B2: vasodilation

19

adrenergic (SNS) agonists
BP

a1, B1: increased BP
used for hypotensive shock

B2: decreased BP (if unopposed by a1)

20

adrenergic (SNS) agonists
lung

B2: bronchodilation
used clinically for asthma

21

adrenergic (SNS) agonists
eye

a1: mydriasis
used for eye exams

B: increased humor production

22

adrenergic (SNS) agonists
GI/GU

a2: GI relaxation, through decreased ACh release

B2-3: smooth muscle relaxation (bladder)

a1: close sphincter
--used to promote continence

B2: uterine relaxation
--used for premature labor

23

adrenergic (SNS) agonists
NMJ

b2: adverse effects: muscle tremors

24

adrenergic (SNS) agonists
CNS

increases vigilance and focus

used in ADHD

25

adrenergic (SNS) antagonists
heart

B1:
1. decreased HR/contractility
2. used clinically for HTN, angina, arrhythmia, CHF

B1: SE: bradycardia, heart block

26

adrenergic (SNS) antagonists
blood vessels

a1: vasodilation
used for HTN

B2: SE: vasoconstriction, decreased perfusion

27

adrenergic (SNS) antagonists
BP

A1/B1: decreased BP
used for HTN

A2 agonist: decreased BP
used for HTN--via central effect at vasomotor
SE: dry mouth, sedation

28

adrenergic (SNS) antagonists
lung

B2: bronchospasm

29

adrenergic (SNS) antagonists
eye

B1-2:
decreased aqueous humor production--> decreased IOP

clinically used for glaucoma

30

adrenergic (SNS) antagonists
GI/GU

a1: open sphincter (ease voiding)

clinically used for: micturition disorders or BPH

31

adrenergic (SNS) antagonists
CNS

B: used for stage fright, essential tremor

SE: depressed mood, sleep disturbances

32

drugs for a1
adrenergic (SNS) antagonists

1. prazosin
2. doxazosin
3. terazosin

33

drugs for B1
adrenergic (SNS) antagonists

1. metaprolol
2. atenolol

34

drugs B1-2
adrenergic (SNS) antagonists

propranolol

35

drugs for a1, B1, B2
adrenergic (SNS) antagonists

1. lebetalol
2. carvedilol

36

adrenergic (SNS) antagonists
a2 agonist drugs

clonidine