Hardy-Weinberg Flashcards
0
Q
Normal allele frequency =
Mutant allele frequency =
A
p
q
1
Q
Hardy-Weinberg eqn
A
p^2 + 2pq + q^2 = 1
where p+q = 1
2
Q
proportion of affected individuals =
A
q^2
3
Q
proportion of unaffected (non-carrier) indivudials
A
p^2
4
Q
proportion of carriers (carrier frequency) =
A
2pq
5
Q
Allele frequencies in the next generation?
A
Same. Equilibrium is an assumption
6
Q
In the case of Beta-thalassemia, what is the proportion of matings that produce affected offspring?
A
(2pq)^2
…homozygous individuals with Beta-Thalassemia are assumed to not reproduce due to the severity of the disease
