Hedgehog signalling

Question 1

What genes are involved in the Hh loop?

Answer 1

Hh-> wingless-> engrailed

Question 2

What 2 things are added to the hedgehog protein?

Answer 2

Cholesterol molecule added

Fatty acid chain added

Question 3

What happens when Hh bind to Ptc?

Answer 3

It inhibits the inhibitory repression from Ptc on Smo

Question 4

What is included in the Ci cytosolic degradation complex?

Answer 4

Fused

Costal 2

Question 5

What does Smo recruit when it translocates to the plasma membrane?

Answer 5

Fused
Costal 2
Ci

Question 6

What does Gli1 do?

Answer 6

Activate Hh pathway