HEMA 2 LEC - Mature Lymphoid Neoplasms 3 Flashcards Preview

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Flashcards in HEMA 2 LEC - Mature Lymphoid Neoplasms 3 Deck (44):
1

• Large atypical cells with pleomorphic nuclei and abundant cytoplasm.

Anaplastic Large Cell Lymphoma

2

• Expression of CD30 antigen and ALK protein

Anaplastic Large Cell Lymphoma

3

• If with fibrosis: anaplastic large cell lymphoma may resemble ____

Hodgkin lymphoma

4

t(2;5)(p23;35) between the ALK and nucleophosmin genes

Anaplastic Large Cell Lymphoma

5

t(2;5)(p23;35)

Anaplastic Large Cell Lymphoma

6

• Pan–T-cell markers (CD3, CD7, CD5): often absent

Anaplastic Large Cell Lymphoma

7

• Proportion of cells are large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei, so-called hallmark cells

Anaplastic Large Cell Lymphoma

8

Cells found in Anaplastic Large Cell Lymphoma
large with abundant cytoplasm and pleomorphic, eccentric, kidney-shaped nuclei

Hallmark cells

9

• One of the most common lymphomas in the pediatric population (10% to 15% of childhood lymphomas) disseminated nodal disease with constitutional symptoms

Anaplastic Large Cell Lymphoma

10

most important prognostic feature of Anaplastic Large Cell Lymphoma

expression of ALK protein

11

___disease has a favorable prognosis: ALK+ or ALK-

ALK+

12

___disease shows survival rates more comparable to those for peripheral T-cell lymphoma, unspecified: ALK+ or ALK-

ALK-

13

2 categories of Hodgkin lymphoma

o Nodular lymphocyte-predominant Hodgkin lymphoma
o Classical Hodgkin lymphoma

14

• B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of reactive lymphocytes

Nodular lymphocyte-predominant Hodgkin lymphoma

15

do cells of Nodular lymphocyte-predominant Hodgkin lymphoma show EBV infection

No

16

• heterogenous group of lymphoid neoplasms derived from the germinal center.
• presence of relatively few diagnostic neoplastic cells, Reed-Sternberg cells, in a rich reactive background

Classical Hodgkin Lymphoma

17

in the United States and Europe, it is a common form of lymphoma occurring in young adults

Classical Hodgkin Lymphoma

18

subtypes of Classical Hodgkin Lymphoma (4)

1. Nodular sclerosis
2. Mixed cellularity

3. Lymphocyte rich

4. Lymphocyte depleted

19

what cells are present in all subtypes of classical Hodgkin lymphoma

reed-sternberg cells

20

large lymphoid cell with a bilobed nucleus or two nuclei with prominent eosinophilic nucleoli and abundant cytoplasm (what cell which is present in classical Hodgkin lymphoma)

reed-sternberg cells

21

what cell is pathognmonic for Classical Hodgkin Lymphoma

reed-sternberg cells

22

variants of reed-sternberg cells
large mononuclear lymphoid cells with an oval nucleus, thick nuclear membrane, distinct eosinophilic nucleolus, and abundant cytoplasm

Hodgkin cells

23

variants of reed-sternberg cells - degenerated or apoptotic cells with a pyknotic nucleus and condensed cytoplasm

Mummified cells

24

variants of reed-sternberg cells - occur predominantly in the nodular sclerosis variant of classical Hodgkin lymphoma and are characterized by a lobated nucleus and artifactual retraction of the cytoplasm secondary to formalin fixation. Because of this artifact, the cells appear to be situated in a clear space

Lacunar cells

25

which category of hodgkin lymphoma show EBV infection

classical hodgkin lymphoma

26

what subtype of classical hodgkin lymphoma
presence of broad collagen bands transecting the lymph node, thickening of the nodal capsule and lacunar cells

Nodular sclerosis classical Hodgkin lymphoma

27

most common of all the subtypes of classical Hodgkin lymphoma, accounting for 70% of cases

Nodular sclerosis classical Hodgkin lymphoma

28

what subtype of classical hodgkin lymphoma
background cellularity includes small lymphocytes, eosinophils, and histiocytes

Nodular sclerosis classical Hodgkin lymphoma

29

what subtype of classical hodgkin lymphoma
• frequency of immunohistochemically demonstrable EBV infection is lowest in this variant

Nodular sclerosis classical Hodgkin lymphoma

30

what subtype of classical hodgkin lymphoma
Reed-Sternberg cells and their variants scattered among the diffuse background proliferation of small lymphocytes, histiocytes, eosinophils, neutrophils, and plasma cells.

Mixed cellularity classical Hodgkin lymphoma

31

what subtype of classical hodgkin lymphoma
Typical Reed-Sternberg cells, mononuclear Hodgkin cells, and mummified cells are seen; however, lacunar cells are absent.

Mixed cellularity classical Hodgkin lymphoma

32

what subtype of classical hodgkin lymphoma
fibrotic bands and capsular thickening are not seen

Mixed cellularity classical Hodgkin lymphoma

33

what subtype of classical hodgkin lymphoma
Scattered mononuclear Hodgkin and Reed-Sternberg cells seen along with a vaguely nodular background of small lymphocytes

Lymphocyte-rich classical Hodgkin lymphoma

34

what subtype of classical hodgkin lymphoma
Nodules represent remnants of mantle zones and residual germinal centers

Lymphocyte-rich classical Hodgkin lymphoma

35

what subtype of classical hodgkin lymphoma
Background cellularity is less heterogeneous

Lymphocyte-rich classical Hodgkin lymphoma

36

what subtype of classical hodgkin lymphoma
Uncommon variant of classical Hodgkin lymphoma

Lymphocyte-depleted classical Hodgkin lymphoma

37

what subtype of classical hodgkin lymphoma

Predominant in immunodeficient patients

Lymphocyte-depleted classical Hodgkin lymphoma

38

what subtype of classical hodgkin lymphoma

Scarcity (paucity) of cells of reactive background

Lymphocyte-depleted classical Hodgkin lymphoma

39

what subtype of classical hodgkin lymphoma

Neoplastic Reed-Sternberg cells and their variants are much more frequent
• Cells show evidence of EBV infection

Lymphocyte-depleted classical Hodgkin lymphoma

40

only subtype of classical Hodgkin lymphoma which occurs in slightly older population (because majority: young adults)

lymphocyte-rich variant

41

only subtype of classical Hodgkin lymphoma which does not involve peripheral lymph node

nodular sclerosis

42

subtype of classical Hodgkin lymphoma which shows mediastinal lymphadenopathy

nodular sclerosis

43

subtype of classical Hodgkin lymphoma which
with the best prognosis

nodular sclerosis

44

subtype of classical Hodgkin lymphoma which is the most aggressive variant of classical Hodgkin lymphoma especially in HIV-positive patients

Lymphocyte-depleted Hodgkin lymphoma

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