HEMA-IMMUNO CASE 1 & 2

Question 1

MALT lymphoma of the skin may be related to which of the following?

a. Chlamydophilia psittaci
b. Campylobacter jejuni
c. Borrelia burgdoferi
d. Hepatitis C virus

Answer 1

C.

Chlamydophilia psittaci - eyes/conjunctiva
Campylobacter jejuni - intestines

Question 2

The following are associated with EBV infection, except:

a. Primary CNS diffuse large B-cell lymphoma
b. Adult T-cell Leukemia
c. Burkitt’s lymphoma
d. Extranodal NK/T-cell lymphoma, nasal type

Answer 2

B.

Question 3

It is most common in children and mostly associated with immunosuppression and autoimmune diseases

a. Burkitt’s lymphoma
b. DLBCL
c. Follicular lymphoma
d. Lymphoblastic lymphoma

Answer 3

B.

Question 4

Most common translocation is t(2:5)

a. AITL
b. MCL
c. MALT
d. ALCL

Answer 4

D.

Question 5

Which of the following is true about Hodgkin lymphoma?

a. More frequent involvement of multiple peripheral nodes
b. Noncontiguous spread
c. Orderly spread by contiguity
d. Extranodal presentation common

Answer 5

C.

Question 6

Which of the following is true about diffuse large B-cell lymphoma?

a. Most common form of indolent non-Hodgkin lymphoma in US
b. Strongly associated with chromosomal translocations involving BCL2
c. Hallmark is (14; 18) translocation
d. Relatively large size lymphocytes, diffuse pattern of growth

Answer 6

C.

Question 7

HTLV-1 infection is associated with which of the following T-cell neoplasms?

a. Peripheral T-cell lymphoma, unspecified
b. Anaplastic large cell lymphoma
c. Adult T-cell leukemia
d. Mycosis fungoides/Sezary syndrome

Answer 7

C.

Question 8

Which of the following T-cell neoplasms is characterized by presence of rearrangements in ALK gene on chromosome 2p23?

a. Peripheral T-cell lymphoma, unspecified
b. Anaplastic large cell lymphoma
c. Adult T-cell leukemia
d. Mycosis fungoides/Sezary syndrome

Answer 8

B.

Question 9

It is the leading cause of SVCS

a. malignant lymphoma
b. aortic aneurysm
c. thrombosis
d. fibrosing mediastinitis

Answer 9

A.

Question 10

Most significant chest radiographic finding of SVCS

a. pleural effusion
b. widening of the superior mediastinum
c. oppacities

Answer 10

B.

Question 11

It is a potentially life-threatening complication of SCVS

a. upper airway obstruction
b. pulmonary edema
c. heart failure
d. tracheal obstruction

Answer 11

D.

Question 12

Primary treatment for SVCS

a. radiation therapy
b. chemotherapy
c. endovascular therapy
d. stenting

Answer 12

A.

Question 13

It is accurate for staging to assess lympadenopathy for indolent lymphomas

a. CT scan
b. PET scan
c. MRI
d. FDG-PET

Answer 13

A.

FDG-PET - aggressive dse

Question 14

It is sensitive for detecting both nodal and extranodal sites involved by NHL

a. CT scan
b. PET scan
c. MRI
d. FDG-PET

Answer 14

D.

Question 15

It is useful in detecting bone, bone marrow, and CNS dse in the brain and spinal cord

a. CT scan
b. PET scan
c. MRI
d. FDG-PET

Answer 15

C.

Question 16

The following are clinical risk factors, except:

a. age >60 years old
b. <70 Karnofsky
c. <1 site of extranodal involvement
d. serum lactate dehydrogenase levels elevated

Answer 16

C.

Question 17

A 65year old male, wheelchair-borne presents with fever, he also complained of night sweats, upon history taking, he was noted to have weight loss and is only capable of limited self care, and laboratory examinations revealed elevated LDH. What is patient’s ECOG score?

a. 1
b. 2
c. 3
d. 4

Answer 17

D.

Question 18

A 65year old male, wheelchair-borne presents with fever, he also complained of night sweats, upon history taking, he was noted to have weight loss and is only capable of limited self care, and laboratory examinations revealed elevated LDH. He previously undergone chemotherapy with R-CHOP. What is the patient’s prognosis?

a. good
b. intermediate
c. poor

Answer 18

C.

Question 19

Form of Burkitt’s lymphoma that presents as a jaw tumor and are EBV-positive

a. endemic
b. nonendemic
c. immunodeficiency-related

Answer 19

A.

Question 20

The following statements are true about Burkitt’s lymphoma, except:

a. BL has a male predominance
b. positive for B-cell antigens CD19 and CD20
c. tumor consists of proliferation of large, atypical lymphocytes giving rise to classic “starry sky” appearance
d. majority of nonendemic BLs are EBV negative

Answer 20

C.

Question 21

It is the standard first line of therapy for DLBCL

a. Rituximab, Cyclophosphamide, Dacarbazine, Vincristine, Prednisone
b. Rituximab, Cyclophosphamide, Dacarbazine, Vinblastin, Prednisone
c. Rituximab, Cyclophosphamide, Doxorubicin, Vinblastin, Prednisone
d. Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone

Answer 21

D.

Question 22

WHO classification of Follicular lymphoma that is aggressive and is most similar to DLBCL

a. Grade IIa
b. Grade II
c. Grade III
d. Grade IIIb

Answer 22

D.

Question 23

The following are true about anaplastic large-cell lymphoma

a. disease of older individuals
b. most closely resembles CD4+ follicular helper T cells
c. localized within the lymph node sinuses
d. pathognomonic malignant “flower cell”

Answer 23

C.

Question 24

Treatment for patient with advanced stage Hodgkin’s Lymphoma

a. R-CHOP
b. radiotherapy
c. ABVD
d. EPOCH-R

Answer 24

C.

Question 25

Associated with Sezary Syndrome

a. AITL
b. ALCL
c. ATLL
d. mycosis Fungoides

Answer 25

D.