HEMA LEC 2 - MDs Classification Flashcards Preview

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Flashcards in HEMA LEC 2 - MDs Classification Deck (13):
1

BM
Unilineage dysplasia: ≥10% of cells in one myeloid lineage

RCUD

2

PB
Unicytopenia*
No or rare blasts (

RCUD

3

PB
Anemia
No blasts

RARS

4

BM
≥15% of erythroid precursors are ringed sideroblasts Erythroid dysplasia only

RARS

5

PB
Cytopenia(s)
No or rare blasts (

RCMD

6

Dysplasia in ≥10% of cells in two or more myeloid lineages
(neutrophil and/or erythroid precursors and/or megakaryocytes)

RCMD

7

– 5% to 9% blasts in BM/ 2% - 4% blasts in PB


RAEB-1

8

-w/ Auer rods (regardless of blast count)

RAEB-2

9

10% to 19% blasts in BM/
5% - 19% blasts in PB

RAEB-2

10

Affects predominantly women

Myelodysplastic Syndrome with Isolated del(5q) (5q-syndrome)

11

Refractory anemia w/o other cytopenias and/or thrombocytosis, hypolobulated megakaryocyte, erythroid hypoplasia

Myelodysplastic Syndrome with Isolated del(5q) (5q-syndrome)

12


Are subtypes of MDS that initially lack the specific changes necessary for classification into other MDS categories

Myelodysplastic Syndrome, Unclassifiable

13

Thalidomide analogue; effective in patients with isolated del(5q) and addit’l cytogenetic abnormalities

Lenalidomide (Revlimid) -

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