HEMA LEC 2 - MDs/MPNs Classification Flashcards Preview

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Flashcards in HEMA LEC 2 - MDs/MPNs Classification Deck (11):
1

-persistent monocytosis of > 1.0 monocyte x 10^9/L

Chronic Myelomonocytic Leukemia

2

-increased WBC count with absolute monocytosis

Chronic Myelomonocytic Leukemia

3


-characterized by leukocytosis with dysplastic neut and their precursors

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

4

multilineage dysplasia → common

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

5

dyspoiesis may be seen in all cell lines, but most remarkable in neut, which may exbit Pelger-Huet-like cells, hypogranularity and bizarre segmentation

Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (aCML)

6

-with strong association with neurofibromatosis type 1

Juvenile Myelomonocytic Leukemia

7

-clonal disorder characterized by proliferation of the granulocytic and monocytic cell lines

Juvenile Myelomonocytic Leukemia

8

-affects children from 1month to 4 y/o

Juvenile Myelomonocytic Leukemia

9

-allogeneic stem cell transplantation effective in about half of patients

Juvenile Myelomonocytic Leukemia

10


-includes cases that meet the criteria for MDS/MPN but do not fit into one of the specified subcategories

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

11

-features of RARS-T and also carries the JAK2 V617F mutation

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

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