HEMA LEC - Erythrocyte Inclusions And Associated Diseases Flashcards Preview

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Flashcards in HEMA LEC - Erythrocyte Inclusions And Associated Diseases Deck (30):
1

Usually orthochromic normoblasts (metarubricyte) but can appear in any erythrocytic stage of maturation

Nucleated RBCs (nRBCs, nucRBCs)

2

Indicate bone marrow stimulation or increased erythropoiesis

Nucleated RBCs (nRBCs, nucRBCs)

3

Associated with thalassemia major, sickle cell anemia, and other hemolytic anemias, erythroleukemia, and myeloproliferative disorders

Nucleated RBCs (nRBCs, nucRBCs)

4

Normal newborns can have a few

Nucleated RBCs (nRBCs, nucRBCs)

5

Healthy individuals should have none on a peripheral blood smear.

Nucleated RBCs (nRBCs, nucRBCs)

6

Small, round DNA fragments (0.5-1.0um in diameter) usually one per cell, but can be multiple which results from karyorrhexis or nuclear disintegration

Howell-Jolly bodies

7

Stain dark purple to black with Wright’s stain; positive (+) in Feulgen Reaction

Howell-Jolly bodies

8

Not seen in normal erythrocytes; normally pitted by splenic macrophages

Howell-Jolly bodies

9

karyorrhexis or nuclear disintegration

Howell-Jolly bodies

10

d. Seen in sickle cell anemia, beta-thalassemia major, and other severe hemolytic anemias, MEGALOBLASTIC ANEMIA, alcoholism, post-splenectomy, accelerated erythropoiesis

Howell-Jolly bodies

11

Multiple, tiny, fine, or coarse inclusion (ribosomal RNA remnants) evenly dispersed throughout the cell;

Basophilic stippling (punctuate basophilia)

12

“blueberry bagel” appearance

Basophilic stippling (punctuate basophilia)

13

Stain dark blue with Wright’s stain

Basophilic stippling (punctuate basophilia)

14

Seen in in thalassemias, megaloblastic anemias, sideroblastic anemia, LEAD POISONING, pyrimidine-5-nucleotidase deficiency, and alcoholism

Basophilic stippling (punctuate basophilia)

15


Small, irregular, dark-staining IRON granules usually clumped together at PERIPHERY of the cell

Pappenheimer bodies

16

Stain with Perl’s Prussian blue stain; appear dark violet with Wright’s stain

Pappenheimer bodies

17

Caused by an accumulation of ribosomes, mitochondria, and iron fragments

Pappenheimer bodies

18

Seen in sideroblastic anemia, hemoglobinopathies, thalassemia megaloblastic anemia, myelodysplastic syndrome (RARS)!!!

Pappenheimer bodies

19

Thin, red-violet, single to multiple ringlike structures that may appear in lip or figure-eight shapes

Cabot rings

20

Seen in megaloblastic anemia, myelodysplastic syndromes, lead poisoning

Cabot rings

21

Composed of fragments of nuclear material, specifically, remnants of microtubules of mitotic spindle

Cabot rings

22

Condensed, intracellular, rod-shaped crystal, or hexagonal crystals with blunt ends and stains darkly

Hemoglobin C crystals

23

Seen in hemoglobin C or SC disease, but not in trait

Hemoglobin C crystals

24

1-2 blunt, fingerlike projection extending from the cell membrane

Hemoglobin SC crystals (Washington monument)

25

Seen in hemoglobin SC disease

Hemoglobin SC crystals (Washington monument)

26

Multiple inclusions ranging in size from 0.3 to 2.0um
Invisible with Wright’s stain; must use a supravital stain to visualize; usually crystal violet

Heinz bodies

27

Seen in G6PD deficiency, beta-thalassemia major, Hgb H disease, unstable hemoglobinopathies, drug-induced anemias

Heinz bodies

28

Represent denatured hemoglobin

Heinz bodies

29

include P. vivax, P, falciparum, P. malariae and P. ovale

Malarial parasite

30

protozoan inclusion (B. microti), transmitted from deer to humans by tick bite. RBC inclusion resembles that of P. falciparum rings which a characteristic “MALTESE CROSS” appearance

Babesia

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