HEMA LEC - RBC Content and Distributions and Assoc Diseases Flashcards Preview

► Med Misc 05 > HEMA LEC - RBC Content and Distributions and Assoc Diseases > Flashcards

Flashcards in HEMA LEC - RBC Content and Distributions and Assoc Diseases Deck (32):
1

Cells have the normal one-third clear, central pallor area

Normochromasia

2


a. Central pallor area is greater than one-third the diameter of the cell

Hypochromasia

3

MCH and MCHC usually decreased

Hypochromasia

4

Often associated with microcytosis

Hypochromasia

5

Seen in iron-deficiency anemia, thalassemias, anemia of chronic disease, sideroblastic anemia, myelodysplastic syndromes

Hypochromasia

6

hypochromasia grading
Area of central pallor is one half of cell diameter

1+

7

hypochromasia grading
Area of central pallor is two third of cell diameter

2+

8

hypochromasia grading
Area of central pallor is three fourth of cell diameter

3+

9

hypochromasia grading
Thin rim of haemoglobin

4+

10

Variation in hemoglobin content showing a slight blue tinge when stained with Wright’s stain; residual RNA

Polychromasia

11

Indicates reticulocytosis; supravital reticulocyte stain to enumerate

Polychromasia

12

polychromasia indicates ____

reticulocytosis

13

Usually slightly macrocytic

Polychromasia

14

polychromasia grading
1%

Slight

15

3% polychromasia grading

1+

16

5% polychromasia grading

2+

17

10% polychromasia grading

3+

18

>11% polychromasia grading

4+

19

(term no longer used)
Current terminology is spherocyte; lacks a central pallor area

Hyperchromasia

20

current terminology for hyperchromasis

spherocyte

21

Stacking or “coining” patterns of erythrocytes due to abnormal or increased plasma proteins

Rouleaux

22

May see excessively blue color to smear macroscopically and microscopically

Rouleaux

23

Seen in hyperproteinemia, multiple myeloma, Waldenstrom

Rouleaux

24

Waldenstrom

Rouleaux

25

To confirm true rouleaux formation, ___________ is employed. A drop of NSS will disperse false rouleaux while true rouleaux remains INTACT

saline replacement

26

saline replacement

Rouleaux

27

Macroglobulinemia, and conditions that produce increased fibrinogen (chronic inflammation)

Rouleaux

28

True rouleaux formation is determined in the ___ area of the peripheral smear.

thin

29

Characterized by clumping of erhthrocytes with no pattern

Agglutination

30

Occurs when erythrocytes are coated with IgM antibodies and complement

Agglutination

31

Seen in cold autoimmune hemolytic anemia (cold agglutinin disease)

Seen in cold autoimmune hemolytic anemia (cold agglutinin disease)

32

Warm blood to 37oC to correct a false low RBC and hematocrit, and false high MCHC (>37g/dL) when using an automated cell counting instrument.

Agglutination

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