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From Flashcardlet > Hematologic - everything > Flashcards

Hematologic - everything Flashcards

(45 cards)

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1
Q

55 year old woman with large lymph nodes

  • dx
  • histo
A
  • Follicular Lymphoma

- cleaved nucleus / butt / Pac man

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2
Q

boy with head and neck lymph nodes

  • dx
  • histo
A
  • Follicular Lymphoma

- cleaved nucleus / butt / Pac man

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3
Q

marrow w/ fried egg appearance

  • dx
  • treatment
A
  • Hairy cell

- deoxycoformin

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4
Q

what gives you massive splenomegaly

A
  • Hairy cell

- primary myelofibrosis

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5
Q

anemic, creatinine high, bones hurt, hypercalcemia

  • dx
  • test
  • histo
A
  • Plasma cell myeloma
  • SPEP and UPEP (see IgG spike)
  • Mott cell
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6
Q

cerebriform cells

  • dx
  • type
A
  • Mycosis fungoides
  • Sezary sydrome
  • T cell (skin)
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7
Q

dry, scaly skin on trunk with enlarged lymph nodes under skin

  • dx
  • treatment
A
  • Mycosis fungoides

- PUVA light

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8
Q

red skin, large lymph nodes, tumor cells in blood, itchy

  • dx
  • blood histo
A
  • Sezary syndrome

- Lutzner and Sezary cells

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9
Q

CCR4

  • dx
  • blood his to
A
  • Sezary syndrome

- Lutzner and Sezary cells

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10
Q

Flower cells (polylobated nuclei)

  • dx
  • virus
  • CD
  • endemic areas
A
  • Adult T cell Leuk/Lymph
  • HTLV-1
  • CD25
  • Japan, Caribbean, Central Africa
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11
Q

Wreath cells

  • dx
  • translocation
A
  • Anaplastic large cell lymphoma

- t(2;5)

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12
Q

ineffective erythropoiesis that doesn’t respond to iron

  • dx
  • type
A
  • Refractory anemia

- myelodysplastic syndrome

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13
Q

dimorphic blood picture

  • dx
  • type
  • contraindication
A
  • Refractory anemia w/ ringed sideroblasts
  • myelodysplastic syndrome
  • don’t give iron!!!
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14
Q

ineffective hematopoiesis, 1% blasts

  • dx
  • type
A
  • refractory cytopenia w/ multilineage dysplasia

- myelodysplastic syndrome

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15
Q

ineffective hematopoiesis with increased blasts

  • dx
  • type
A
  • refractory anemia w/ increased blasts

- myelodysplastic syndrome

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16
Q

child, TdT positive, blood problems

  • dx
  • good prognostic factors
A
  • B-ALL

- hyperdiploid, 4-10, WBC low/normal, initial response to therapy

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17
Q

adolescent TdT positive, lymph node or mediastinal mass

  • dx
  • prognosis
A
  • T-ALL

- good

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18
Q

popcorn cells

  • dx
  • CD and other markers
A
  • Nodular Lymphocyte Predominant HL

- CD20, CD45, OCT-2, BOB.1

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19
Q

lacunar variants, fever

  • dx
  • CD markers
Study These Flashcards
A
  • nodular sclerosis HL

- CD15, CD30

20
Q

fibrous bands / capsules, mediastinal involvement

  • dx
  • CD markers
Study These Flashcards
A
  • nodular sclerosis HL

- CD15, CD30

21
Q

enlarged abdominal lymph node and organ involvement

  • dx
  • histo
  • also check for
Study These Flashcards
A
  • Lymphocyte deplete HL
  • almost no small lymphocytes
  • check for EBV and HIV
22
Q

lots of small lymphocytes

  • dx
  • CD markers
Study These Flashcards
A
  • Lymphocyte rich HL

- CD15, CD30

23
Q

Reed Sternberg cells

24
Q

JAK2

Study These Flashcards
A
  • PV
  • Primary MF
  • ET
25
Multinucleated Auer rod cells, DIC - dx - translocation - treatment
- M3 promyelocytic leukemia, PML/RARa - t(15;17) - ATRA
26
Faggot or Sultan cells - dx - translocation - treatment
- M3 promyelocytic leukemia, PML/RARa - t(15;17) - ATRA
27
Glycophorin A, Heme A | - dx
M6 erythroleukemia or erythroid myeloid leukemia
28
Skin & Gingiva involvement
- M5 (monoblastic, monocytic) | - M7 (megakaryoblastic)
29
PMN-monocyte split precursor
M4 myelomonocytic
30
keep classification for life
AML
31
classified on # lineages
myelodysplastic
32
classified on clinical presentation | - & CD markers
T cell | - CD4-8
33
classified on stage of differentiation | - & CD markers
B cells | - CD19, 20, 22
34
hyper cellular bone marrow (grow up)
- myelodysplastic | - myeloproliferative
35
ineffective BM hematopoiesis (don't get in blood)
- myelodysplastic | - AML
36
effective hematopoiesis (get into blood)
- myeloproliferative
37
tyrosine kinase
myeloproliferative (CML, PV, PMF, ET)
38
myeloid CD
CD13, CD33, CD34
39
CD103, 25, 11C
-Hairy Cell
40
visual problems w/ CD19, CD20, CD22 - dx - subtype - immunoglobulin - blood his to - virus
- Waldenstrom Macroglobulinemia - lymphoplasmacytic lymphoma - IgM - Rouleaux - Hep C
41
poikilocytosis (tear drop) - dx - mutation - age
- primary myelofibrosis - JAK2 - 50-60
42
thrombosis and gout
- PV | - PMF
43
can get osteosclerosis - dx - another sx
- PV | - visual problems, gout
44
increased basophils
CML
45
myelofibrosis / dry tap
- primary myelofibrosis - hairy cell - M7

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