hematologic malignancies 2 Flashcards Preview

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Flashcards in hematologic malignancies 2 Deck (12):
1

what type of leukemia is most common in children

acute lymphocytic leukemia (ALL)

2

what are the signs and symptoms of acute lymphocytic leukemia

no urgent symptoms
anemia
CNS symptoms
neutropenia (infection)
blood chemistry findings
splenomegaly, hepatomegaly, and lymphadenopathy

3

what are poor prognostic factors for acute lymphocytic leukemia (ALL)

WBC over 50,000
chromosome abnormalities
males
younger than 1 or older than 10
no remission in first 4 weeks of treatment

4

treatment of acute lymphocytic leukemia (ALL) must include what type of prophylaxis

CNS prophylaxis; drugs must cross BBB

5

what is the low risk induction treatment for children with acute lymphocytic leukemia (ALL)?

vincristine + corticosteroid + pegaspargase

6

What is the high risk induction treatment for children with acute lymphocytic leukemia (ALL)?

vincristine + corticosteroid + pegaspargase + daunorubicin

7

what should be added for induction treatment of adults with lymphocytic leukemia (ALL) and Ph+ disease

imatinib

8

what should be added for induction treatment of adults with lymphocytic leukemia (ALL) and CD20+ disease

rituximab

9

what drugs can be used for lymphocytic leukemia (ALL) maintenance

methotrexate weekly
mercaptopurine PO
vincristine
corticosteroids

10

what drugs can be used for CNS prophylaxis for lymphocytic leukemia (ALL)?

intrathecal methotrexate
intrathecal cytarabine
intrathecal hydrocortisone

11

what drugs can be used for CNS prophylaxis for lymphocytic leukemia (ALL)?

intrathecal methotrexate
intrathecal cytarabine
intrathecal hydrocortisone

12

95% of what type of leukemia patients have a Philadelphia chromosome

chronic myelogenous leukemia (CML)