Hematology -- cancer translocations and cell markers Flashcards Preview

USMLE > Hematology -- cancer translocations and cell markers > Flashcards

Flashcards in Hematology -- cancer translocations and cell markers Deck (15):
1

Reed Sternber cells

CD15 and CD30 (B-cell origin)

2

8,14

Burkitt lymphoma (non hodgkins)

Ig (14), Myc (8)

Myc is a transcripton factor

3

9, 22

Philadelphia chromosome - CML - chronic myleoid leukemia ( non-hodgkins)

Brc (22), Abl (9)

4

14, 18

Follicular lymphoma ( non- hodgkins)

Ig (14), BCL-2 (18)
BCL-2 blocks apoptosis

** Waxing and Waning** lymphadenopathy

5

11, 14

Mantle cell lymphoma ( non- hodgkins)

cyclin D1 (11) Ig (14)

6

15, 17

M3 type of AML
- responds to all- trans retinoic acid

7

8,21

AML seen in patients with down syndrome

8

Markers of T cells

TCR ( binds antigent-MHC complex)
CD3 (associated with TCR for signal)
CD28 (binds B7 on APC)

9

T helper cell cell markers

CD4, CD40L

10

Cytotoxic T cell markers

CD8

11

Regulatory T cell markers

CD4
CD25

12

B cell markers

Ig (binds antigen) -- IgM and IgD are 1st.
CD19, CD20, CD21 (receptor for EBV)
CD40 (binds to T-helper cell)
MHC II
B7 (helps activate B cells)

13

Macrophage cell markers

CD14 **
CD40
MHC II
B7

14

Natural Killer cell markers

CD 16** (binds Fc of IgG)
- antibody dependent cell mediated cytotoxicity
CD56 ** unique marker for NK

15

Hematopoietic stem cell marker

CD34