Hematology MDS Ch 19 Flashcards Preview

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Flashcards in Hematology MDS Ch 19 Deck (17):
1

This type of morphologic characteristic has 3 types
 

Sideroblast

2

Name this classification of MDS:

•Dx rests on quantitative criteria:

  • Presence of at least 15% ringed sideroblasts in the BM

•Ringed Sideroblasts

  • Pathologic sideroblasts in which the usual migration of mitochondria from the nucleus does not occur
  • Result: remain frozen around the nucleus, where insoluble iron conglomerates and further contributes to cell destruction

•Lab Features

  • RBCs macrocytic or normocytic with dimorphic features
  • Leukopenia
  • Thrombocytopenia

RARS: Refractory anemia with ringed sideroblasts

3

Name this classification of MDS:

•Degree of lineage dysplasia more significant

•Blasts ranges from 5% to 20%

•Dysgranulopoiesis with nuclear hyposegmentation and hypogranulation is frequent

•Thrombocytopenia

RAEB: Refractory anemia with excess blasts

4

Name this classification of MDS

•Blasts ranges from 20% to 30%

•PB blast >5% and may contain auer rods

•Acute myeloblastic leukemia M2 can mimic this subtype

RAEB-t: refractory anemia with excess blasts in transformation

5

Name this classification of MDS

•Cytogenetics means of distinguishing from CML

•BM hypercellular

•Presence of more than 1 X 109 /L monocytes in PB

CMML: Chronic myelomonocytic leukemia

6

Which type of anemia is most common in MDS?

a. Microcytic, hypochromic

b. Normocytic, hypochromic

c. Macrocytic, normochromic

d. Domorphic

c. Macrocytic, normochromic

7

Which of the following morphological abnormalities are helpful in the diagnosis of MDS?

a. Pseudo-Pelger-Huet and hypogranulation

b. Ringed sideroblasts

c. Micromegakaryocytes, monolobular megakaryocytes

d. all of the above

d. all of the above

8

Which of the following criteria will differentiate RAEB-t from AML of the M2 type?

a. thrombocytopenia

b. anemia

c. The finding of t(8;21)

d. blasts less than 5%

c. The finding of t(8;21)

9

Which of these cell surface antigens is of prognostic significance in MDS?

a. CD 19

b. CD HLA-DR

c. CD 34

d. CD 33

c. CD 34

10

Which one of these MDS subgroups has the most favorable prognosis?

a. RAEB

b. CMML

c. RA

d. RARS

d. RARS

11

Which type of treatment may offer a cure in patients with MDS?

a. Chemoradiotherapy

b. Allogeneic bone marrow transplantation

c. Autologous bone marrow transplantation

d. Growth factors such as G-CSF

b. Allogeneic bone marrow transplantation

12

Which of the following agents may lead to secondary MDS (sMDS)?

a. Hydrocortisone

b. Alkylating agents

c. Irradiated blood components

d. Folic acid

b. Alkylating agents

13

Which of the following is most likely to affect prognosis in MDS?

a. Leukopenia

b. Increased bone marrow myeloblasts

c. Erythroid hyperplasia

d. Thrombocytosis

b. Increased bone marrow myeloblasts

14

In female patients with RA and elevated platelet counts which chromosome abnormality is most often found?

a. 5q-

b. t(8;21)

c. 7q-

d. t(15;17)

a. 5q-

15

Which of the following biologic or genetic anomalies are important in the pathogenesis of MDS?

a. Chromosomal translocations

b. Chromosomal deletions

c. Hemolysis

d. Increased intramedullary apoptosis

b. Chromosomal deletions

16

Which of the MDS subtypes is more closely related to the chronic myeloproliferative disorders?

a. RAEB

b. CMML with WBC > 13 X 109/L

c. CMML with WBC < 13 X 109/L

d. RARS

b. CMML with WBC > 13 X 109/L

17

Which MDS scoring system is most often used today?

a. FAB

b. IPSS

c. Sanz

d. Bournemouth

b. IPSS