Hematopoiesis Flashcards Preview

DPPT Unit 2 > Hematopoiesis > Flashcards

Flashcards in Hematopoiesis Deck (24):
1

In what week of gestation does fetal hematopoiesis begin?

Week 3

2

What is the sequence of embryonic organs that take over hematopoiesis?

Young (1) Liver (2) Synthesizes (3) The (4) Blood
(1) Liver
(2) Spleen
(3) Thymus
(4) Bone marrow

3

What are the five white blood cell types, in order of prevalence?

Never Let Monkeys Eat Bananas
(1) Neutrophils
(2) Lymphocytes
(3) Monocytes
(4) Eosinophils
(5) Basophils

4

When does medullary hematopoiesis (in bone marrow) begin in the fetus?

5 months of gestation

5

What is a characteristic feature of stem cell division in hematopoiesis?

Asymmetry - one cell retains properties of the stem cell

6

What are two causes of induced hematopoiesis?

(1) Infection leads to increased production of neutrophils
(2) Anemia leads to increased production of RBCs

7

What do stromal cells in bone marrow do?

(1) Nurture and protect stem cells, (2) secrete factors that are chemotactic for hematopoietic cells

8

Where are bone marrow aspirations drawn from in children?

Anterior tibia

9

What is the term for replacement of cellular bone marrow with fat? At what age does this occur?

Involution at 5-7 years

10

After ~20 years, where is cellular marrow found?

(1) Sternum
(2) Ribs
(3) Pelvis
(4) Vertebrae
(5) Skull
(6) Scapulae
(7) Proximal ends of long bones

11

How long does it take reticulocytes to mature to RBCs?

About 3 days (2 in bone marrow + 1 in peripheral blood)

12

What is a marker for hematopoietic stem cells?

CD34

13

Where are neutrophils found?

(1) 50% in marginal neutrophil pool and (2) 50% in circulating neutrophil pool

14

What do steroids do to neutrophil populations?

Movement from marginal neutrophil pool to the circulating neutrophil pool

15

How long do neutrophils circulate?

10-14 hours

16

What is the life span of RBCs and platelets?

RBCs: 120 days
Platelets: 7-10 days

17

When are hypersegmented neutrophils found?

Folate and vitamin B12 deficiency

18

What are G-CSF and GM-CSF and what do they do?

Granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor - stimulate differentiation and mobilization of stem cells into peripheral blood

19

What stimulates the differentiation and maturation of megakaryoblasts and megakaryocytes?

Thrombopoietin (TPO)

20

Where are bone marrow aspirations drawn from in adults?

Posterior superior iliac crest

21

What is the term for variation in RBC diameter on blood film?

Anisocytosis

22

What are the staining characteristics in Wright stain?

(1) Methylene blue stains acidic structures blue (basophils)
(2) Eosin stains basic structures pink (eosinophils)
(3) Neutrophils are purple from being stained by both methylene blue and eosin

23

What is a band shift or left shift?

(1) Increase in bands and immature neutrophils in peripheral blood (2) due to proliferation of myeloid cells

24

What is a consequence of hematopoiesis occurring throughout the skeleton in children?

Hyperactive immunity