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Flashcards in Hematopoiesis Deck (16)
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1

Where are the majority of hematopoiesis done in each trimester?

1. Yolk sac
2. Liver (small amount in spleen)
3. Bone marrow

2

Where are RBCs made in the bone marrow?

The hematopoietic cell compartment

3

In the marrow stomal compartment, what is responsible for platelet production?

Endothelial cells

4

What cell type consumes the nucleus of RBC after they have extruded?

Macrophages

5

What is the primary form of bone marrow in the medullary cavity of adult bones? Is this active or inactive in erythropoiesis?

Yellow bone marrow, inactive

6

What are the committed precursors?

Myeloid stem cells (RBC, platelets, monocytes, neutrophils, basophils, eosinophils) and lymphoid stem cells (B and T cells)

7

What interleukin is used for myeloid stem cells?

SCF then IL3

8

What IL are used for lymphoid stem cells?

1 and 4

9

What is used to treat neutropenia after chemotherapy or bone marrow transplant?

G-CSF (granulocyte colony-stimulating factor)

10

Where are EPO and TPO primarily produced? What do they produce?

EPO - kidney and stimulates the production of RBC

TPO - produced in liver and stimulates an increase in megakaryocytes and platelets

11

What is the role of RBC and platelets?

RBC - pick up O2 in lungs and drop in tissue; pick up CO2 in tissues and drop in lungs
Platelets - secrete vasoconstrictors and form a temporary plug

12

Polychromatophilic erythroblast show what characteristic?

3rd stage of 5

checkerboard pattern nucleus

13

The first stage after the nucleus has been extruded?

Polychromatophilic erthrocyte (reticulocyte)

14

Reticulocytes shave to be stained with _______________ which causes the ______________ to clump

Supravital stain, ribosomes

15

Basophillic erythroblasts are different in that they have coarse _____________ and they have a _______________ nucleus:cytoplasm ratio

Chromatin, decreased

16

What is the order of erythropoiesis?

1. Proerythroblast
2. Basophilic erythroblast
3. Polychromatophilic erythroblast
4. Orthochromatophilic erythroblast
5. Reticulocyte