Hematopoietic II Flashcards Preview

Pathology Exam 4 > Hematopoietic II > Flashcards

Flashcards in Hematopoietic II Deck (22):
1

absolute polycythemia

RBC elevation. dark skin/mucosa. myeloprioliferatice issue or high erthyropoeitin.

2

relative polycythemia

hemaconcentration decreases due to loss of fluid volume

3

leukopenia def.

decrease in WBC (probably infection)

4

neutropenia/agranulocytosis

marrow hypercellularity because of increased precursors. (drugs cause opposite)

5

lymphadenitis

reactive, large germinal centers. neutrophilic abscesses, hyperplasia. follows infection. normal

6

leukemia def

bone marrow tumor where cells spill into blood. often tyrosine kinase mutations

7

acute myelogenous leukemia

immature myeloid cells.

8

acute promyelocytic leukemia

transcription factor mutation, blasts!. PML fusion protein, needs retinoid acid.

9

chronic myelogenous leukemia (CML)

hyper proliferation of neoplastic myeloid progenitors. terminal differentiate. fusion protein> GF INDEPENDENT!BCR/ABL. tyrosine kinase ON

10

lymphoma def

tumors with masses in lymph nodes, spleen, extra nodal tissues

11

diffuse large B cell lymphoma

BCL 6/2 rearrangement

12

burrito lymphoma

non hodgkin, lots of mitotic figures, starry sky, extra nodal tumors. EBV association. MYC oncogene

13

Hodgkin lymphoma

reed sternberg/owl eye cells. B lymphocyte neoplasms.

14

multiple myeloma

D cyclin/chromosome translations, loss of proliferation. demineralized bone, mature stem cells? IgG droplets

15

splenomegaly

infections, inflammation, anemia, HTN, neoplasms

16

thymoma

well incapsulated tunic neoplasm. often paraneoplastic syndrome associated

17

reed sternberg cells

hodgkin lymphoma

18

ben jones cells

multiple myeloma

19

d cyclin mutation in

multiple myeloma

20

myc gene mutation inn

burkitts lymphoma

21

polycythemia vera

erythropoietin independent growth

22

band cells present in

leukocytosis