Flashcards in Hematopoietic II Deck (22):
RBC elevation. dark skin/mucosa. myeloprioliferatice issue or high erthyropoeitin.
hemaconcentration decreases due to loss of fluid volume
decrease in WBC (probably infection)
marrow hypercellularity because of increased precursors. (drugs cause opposite)
reactive, large germinal centers. neutrophilic abscesses, hyperplasia. follows infection. normal
bone marrow tumor where cells spill into blood. often tyrosine kinase mutations
acute myelogenous leukemia
immature myeloid cells.
acute promyelocytic leukemia
transcription factor mutation, blasts!. PML fusion protein, needs retinoid acid.
chronic myelogenous leukemia (CML)
hyper proliferation of neoplastic myeloid progenitors. terminal differentiate. fusion protein> GF INDEPENDENT!BCR/ABL. tyrosine kinase ON
tumors with masses in lymph nodes, spleen, extra nodal tissues
diffuse large B cell lymphoma
BCL 6/2 rearrangement
non hodgkin, lots of mitotic figures, starry sky, extra nodal tumors. EBV association. MYC oncogene
reed sternberg/owl eye cells. B lymphocyte neoplasms.
D cyclin/chromosome translations, loss of proliferation. demineralized bone, mature stem cells? IgG droplets
infections, inflammation, anemia, HTN, neoplasms
well incapsulated tunic neoplasm. often paraneoplastic syndrome associated
reed sternberg cells
ben jones cells
d cyclin mutation in
myc gene mutation inn
erythropoietin independent growth