HEME 2.61 Flashcards Preview

hematology > HEME 2.61 > Flashcards

Flashcards in HEME 2.61 Deck (13)
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1
Q

what was the first oral direct thrombin inhibitor

A

Dabigatran (pradaxa), on the market in 2010

2
Q

what is unique about Dabigatran (Pradaxa)

A

It does not require frequent blood tests for INR

3
Q

when were direct X inhibitors introduced

A

released August 2011

4
Q

what are some examples of Thrombolytics/fibrinolytics

A
  • streptokinase
  • urokinase
  • synthetic tPA
  • others
5
Q

how do Thrombolytics/fibrinolytics function

A

rapidly lyse thrombi by catalyzing the formation of plasmin from plasminogen

6
Q

when do thrombolytics work best

A

the sooner they are initiated from the onset of an event

7
Q

what are the main classes of antiplatelets

A
  • cyclooxygenase inhibitors (mainly aspirin)
  • Thienophyidines (ADP Inhibitors)
  • GP llb/llla inhibitors
8
Q

how does aspirin work

A

inhibits the synthesis of TXA2, one of the substances that helps make the pltelets sticky and more likely to aggregate

9
Q

what is the main drug associated with Thienopyridines (ADP inhibitors)

A

Clopidogrel (plavix)

10
Q

what is an example of a GP llb/llla inhibitor

A

ABCiximab (ReoPro)

11
Q

what is an example of a antifibrinolytics

A

Tranexamic acid

12
Q

how does tranexamic acid function

A

activation of plasminogen to plasmin

13
Q

how is tranexamic acid used in dentistry

A

In the form of 5% mouth rinse after extraction or surgery in patients with prolonged bleeding time