Heme/Lymph-Anemia and Hematopoietic growth factors Flashcards Preview

Pharmacology & Drugs > Heme/Lymph-Anemia and Hematopoietic growth factors > Flashcards

Flashcards in Heme/Lymph-Anemia and Hematopoietic growth factors Deck (17):
1

What are the most common clinical presentations of anemia

-Fatigure, dizziness, pale skin, cold hands/feet, SOB, irregular heartbeat

2

What is the effect of NO during surgery on B12

Inactivates it

3

Which has a longer half life, epoetin Alfa or darbepoetin Alfa

Darbepoetin Alfa

4

What is the MOA for hydroxyurea

*used to treat sickle cell anemia

-targets ribonucleotide reductase, resulting in S phase cell arrest and increased levels of HbF

5

What is the MOA of eculizumab

A against C5 and inhibits splitting and formation of MAC

-Inhibits the thermal complement mediated lysis seen in PNH

6

Which precaution must be take before giving eculizumab

Meningococcal vaccine, because the lack of C5 will increase the risk

7

How does the sargramostim (GM-CSF) and filgrastim (G-CSF) differ on effect of action

-Sargramostim (GM-CSF) act in more locations with proliferation stimulation of every myeloid lineage

-Filgrastim (G-CSF) only acts to stimulate proliferation of basophils and neutrophils

8

Which form of G-CSF lasts longer, pegfilgrastim or filgrastim

Pegfilgrastim due to conj with monomethyl glycol (h/L of 15-80 hours)

9

Which drug can cause “fetal gasping syndrome”

Sargramostin

10

What are the adverse effects of oprelvekin

Aka IL-11

-Edema due to volume expansion
-cardiac dysrhythmias
-allergic reactions
-“bloodshot eyes”

11

Which adverse effects need to be watched with eltrombopag

Hepatotoxicity if used with interferon and ribavirin in patients with Hep-B

12

What are the drugs that commonly cause hemolytic anemia

-Cephalosporins (Ceftriaxone and cefotetan)
-penicillins (piperacillin)

13

What are the drugs that commonly cause thrombocytopenia

-Heparin
-Quinidine and quinine

14

What are the drugs can cause aplastic anemia

-Cancer chemotherapies
-chloramphenicol
-benzene

15

What is a major side effect of the erythropoietin like drugs

Hypertension

16

What is the supplement taken orally for mild anemia

-Ferrous something, such as Ferrous sulfate, ferrous gluconate, ferrous fumarate

17

What is given for anemia in those who have iron malabsorption, intolerance of oral iron, or non compliant

-Iron dextran
-Sodium ferric gluconate complex
-Iron sucrose