Heme/Onc

Question 0

Milan Criteria for OLT in HCC

Answer 0

One lesion <3cm No extra hepatic manifestations No vascular invasion

Question 1

HNPCC criteria

Answer 1

3-2-1 rule: 3 relatives with HNPCC assoc cancer 2 generations 1 person died before 50

Question 2

This hormone always indicates a non-seminomatous component in a testicular tumor

Answer 2

alpha-fetoprotein

Question 4

Follow up surveillance for colon cancer

Answer 4

(1) CT chest/abd/pelvis q1year x 3 years (2) CEA q3-6 months for the first 2 years then q6months for the next 3 years (3) Colonoscopy 1 year, then 3 years later, then q5years

Question 5

CD55 and CD59 on flow cytometry

Answer 5

Paroxysmal nocturnal hemoglobinuria (PNH)

Question 6

ADAMTS13

Answer 6

TTP-HUS

Question 7

Anti-PF4 antibodies

Answer 7

HIT

Question 8

JAK 2 Mutation

Answer 8

• Essential Thrombocythema - Polycythemia Vera - Primary Myelofibrosis

Question 9

9,22 translocation (Philadelphia Chromosome)

Answer 9

Chronic myeloid leukemia

Question 10

How to distinguish alpha-thalassemia trait vs. beta-thalassemia trait in microcytic anemia

Answer 10

Hemoglobin electrophoresis - normal in alpha-thal trait; elevated A2 and fetal hemoglobin in beta-thal trait

Question 11

Treatment of polycythemia vera

Answer 11

• Low-dose aspirin and phlebotomy - Hydroxyurea if: >60 y/o or prior thrombotic event

Question 12

Treatment of chronic myeloid leukemia (CML)

Answer 12

Imatinib - bcr-abl inhibitor

Question 13

Form of AML associated with DIC

Answer 13

Acute promyelocytic leukemia

Question 14

Treatment of acute promyelocytic leukemia (APL)

Answer 14

All-trans-retinoic acid + arsenic trioxide

Question 15

(15;17) gene translocation

Answer 15

Acute promyelocytic leukemia

Question 16

Treatment of 5q- syndrome

Answer 16

Lenalidomide (5q- syndrome is a sub-type of MDS)

Question 17

Smudge cells

Answer 17

Chronic lymphocytic leukemia (CLL)

Question 18

Antibodies to HPA-1a

Answer 18

Posttransfusion purpura

Question 19

Leukoreduction of PRBCs

Answer 19

Decreases the incidence of febrile nonhemolytic transfusion reactions, cytomegalovirus transmission, and alloimmunization

Question 20

Factor(s) that prolong only PTT

Answer 20

8, 9, 11, 12

Question 21

Factor(s) that prolong only PT

Answer 21

Factor 7

Question 22

Treatment of acquired Factor VIII inhibitors

Answer 22

Recombinant Factor VIIa.

Question 23

Blood tests to confirm suspected B12 deficiency

Answer 23

Elevated homocysteine and methylmalonic acid

Question 24

Periorbital purpura and macroglossia

Answer 24

AL amyloidosis

Question 25

Treatment of high-risk MDS

Answer 25

Azacitidine

Question 26

Number of blasts in blood or bone marrow to dx AML

Answer 26

\>20%

Question 27

MDS transforms into...

Answer 27

AML

Question 28

Acute hemolytic transfusion reaction

Answer 28

ABO incompatibility

Question 29

Delayed hemolytic transfusion reaction

Answer 29

Alloantibody that causes rapid clearance of RBCs 1-3 days after transfusion

Question 30

Febrile non-hemolytic transfusion reaction

Answer 30

Donor leukocyte cytokines OR Recipient alloantibodies against donor leukocytes Tx: Leukocyte reduction of further transfusions

Question 31

Transfusion-associated acute lung injury

Answer 31

Donor anti-leukocyte antibodies --\> Leukocytes aggregate in pulmonary capillary bed

Question 32

Transfusion-associated GVHD

Answer 32

Donor lymphocytes engraft in immunocompromised recipient Tx: Gamma-irradiation of blood products

Question 33

Conditions treated with plasmapheresis (plasma exchange)

Answer 33

- Guillain-Barre - Myasthenia gravis - TTP-HUS - Waldenström macroglobulinemia-related hyperviscosity syndrome - Transverse myelitis

Question 34

Bite cells

Answer 34

G6PD

Question 35

INR reversal in life-threatening bleeding

Answer 35

IV vitamin K + Prothrombin complex concentrate (PCC)

Question 36

Overexpression of cyclin D1 and a t(11:14) translocation

Answer 36

Mantle cell lymphoma

Question 37

EGFR inhibitors

Answer 37

Erlotinib (Tarceva) and gefitinib

Question 38

Type of chemo given in testicular cancer

Answer 38

Cisplatin-based

Question 39

Treatment of hairy cell leukemia

Answer 39

Cladribine

Question 40

Chemo used in colon cancer

Answer 40

FOLFOX (5-FU, leucovorin, oxaliplatin)

Question 41

Chemo for CLL

Answer 41

Fludarabine + Rituximab

Question 42

Chemo for Hodgkin lymphoma

Answer 42

ABVD = adriamycin (doxorubicin), bleomycin, vincristine, dacarbazine

Question 43

β2-Microglobuin

Answer 43

Prognostication in chronic lymphocytic leukemia (CLL)

Question 44

Chemo for AML

Answer 44

"7 and 3" cytarabine + anthracycline

Question 45

Answer 45

Bite Cells G6PD deficiency

Question 46

Answer 46

Target cells Alpha- and beta-thalassemia

Question 47

Answer 47

Spherocytes Hereditary spherocytosis; warm autoimmune hemolytic anemia

Question 48

Answer 48

Cold agglutinin disease Erythrocytes are clumped, leading to falsely elevated MCV. Associated with IgM antibodies to erythrocyte antigens.