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Flashcards in Heme/Onc Deck (93)
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1

Anemia, reticulocytosis and increased indirect bilirubin indicates?

hemolytic anemia

2

peripheral blood smear of dysmorphic red blood cells without central pallor describes what?

spherocytes

3

In hemolysis what happens to:
retiulcytes?
LDH?
Haptoglobin

Reticulocytosis
incr. LDH
decreased haptoglobin

4

name two tests for Heridiatry spherocytosis& whats deficient ?

Increased MCHC=> membrane loss & RBC dehyration
Osmotic fragility testing


Spectrin

5

What is used to reverse methotrexate toxicity?

Folinic acid (leucovorin)

6

And what two situations is allopurinol used? How does it work?

Noncompetitive inhibitors of xanthene oxidase used in the treatment of :

gout
Tumor lysis syndrome (also use Rasburicase)

7

When and how does filgrastim work?

G-CSF analog stimulate proliferation/differentiation of granulocytes in patients with NEUTROPENIA

8

When is Mezna used? Which drugs is a given with concurrently?

What does a bind?

Hemorrhagic cystitis
Cyclophosphamide, ifosfamide

Acrolein

9

What do you use to treat anthracycline induced cardiotoxicity?

Dexrazoxane

10

Where does isotype switching occur? Which receptor is necessary?

Germinal centers of lymph nodes requires interaction OCD 40 receptor on B cells

11

Where does the VDJ recombination occur?

During B cell maturation within the bone marrow

12

Name what these diagnostic test correlate to:
Panpanicolaou smear
Cryoglobulins
Hemadsorption in cell culture
Heterophile antibodies

Human papilloma virus
Hepatitis C virus
Influenza/parainfluenza
EBV

13

Which cells exert master control over other cells involved in iron metabolism?

Hepatic parenchymal cells due to intercellular binding protein FERRITIN

14

Purpose of lactoferrin where it is secreted?

Renal tubular cells

Finds two free iron in the urine and recovers from metabolic use

15

What carries out the non-oxidative reactions of the HMP shunt?

Oxidative?

Transketolase
Transaldolase

G6Phosphate dehydrogenase =RLS

16

Which chemo drug would cause burning on urination and urgency?

Cyclophosphamide ifosfamide
Induced hemorrhagic cystitis

17

Which chemo drug would be associated with CHF symptoms?

Doxorubicin

18

Dry cough, exertional dyspnea, pulmonary toxicity is a side effect of which chemotherapy drug?

Bleomycin = >progressive pulmonary fibrosis

19

Alkylating agents of chemotherapeutic agents are associated which which type of symptoms?

Tarry stools
Fatigue

20

Which chemotherapy drug would cause abdominal pain and jaundice what type of drug is this?

Mercaptopurine
S-phase specific purine Analog

21

What diseases associated with factor X I deficiency ? When is bleeding seen?

Hemophilia see

bleeding only occurs in surgical procedures

22

What metabolizes pro carcinogens?

Cytochrome P450 MONOOXYGENASE

23

YOUR MOM

is LOVELY

24

Homocysteine to cystathione
Cofactors
Enzyme

Serine, vitamin B6
Cystathionine synthetase

25

Cystathionine to cysteine

Vitamin B6
Cystathionase

26

Homocystine to methionine
Cofactors
Enzyme
What byproducts are produced?

Methylcobalamin, 5-methyl tetrahydrofolate

Methionine synthase

THF4, cobalamin

27

folic acid to THF ?

What inhibits this? (2)

folic acid-->

DHFReductase |--- methotrexate

DHF-->

DHFReductase |--- methotrexate

THF

THF--->DHF by thymidylate synthetase ( |--- 5-FU)

28

How does leucovorin rescue work?

follinic acid (leucovorin) is not require the action I'm dihydrofolate reductase to be converted to THF and it's unaffected by methotrexate poisoning

29

Germ tubes/true hyphae are diagnostic of which fungi? (aka positive germ tube test)

Three potential manifestations?

Canada albicans

Oral thrush
Vulvovaginal candidiasis-White discharge
Cutaneous candidiasis-maceration/fissuring

30

Attributable risk percentage =?

ARP = (risk and exposed -risk and unexposed)/ risk and exposed

USE:
ARP = (RR -1)/RR