Heme Onc

Question 1

MALT

Answer 1

(11;18) BIRC3;MALT1
(14;18) MALT1;IGH
(1;14) IGH;BCL10
(3;14) FOXP1 with IGH

Question 2

Diffuse large B cell ass with chronic inflammation

Answer 2

PAL is IFI27.
MYC, TP53 and TNFAIP3

Question 3

DLBCL primary mediatinal

Answer 3

Chromosome 2: cREL mutation leading to MAL IHC positivity.
Chromosome 9: JAX2 and PD L1 and 2.

Question 4

Primary effusion lymphoma in HIV

Answer 4

Positive for both EBV and HHV8 (LANA).
Negative for B and T cell makers
HLA-DR, CD30, EMA, CD38 and CD77.