Flashcards in Heme1c Deck (14):
What are the 3 forms of embryonic hb?
a. Gower 1: zeta2 epsilon2
b. Portland: zeta2 gamma2
c. Gower 2: alpha2 epsilon3
What are the chain components in fetal hb?
What are the components, names and percentages in adult hb?
alpha2 delta2, A2, 1.5-3.5%
alpha2 beta2, A, >95%
When does the beta gamma switch happen?
3-4 months gestation is when it begins.
At birth, what percent of Hb is fetal?
What causes a left shift in the O2 dissociation curve?
down: temp, pCO2, 2,3-DPG
hb type: fetal
What causes a right shift in the O2 dissociation curve?
up: temp, pCO2, 2,3-DPG
hb type: adult
Tell me about inheritance and clinical manifestations of G6P deficiency.
X-linked, also many drugs cause it.
Asymptomatic, neonatal hyperbilirubinemia, chronic hemolysis, intermittent hemolysis (stressors,- fava beans).
Late complications: diabetes, renal failure
What do you see on a smear for G6P deficiency?
Heinz bodies and "bites" take out of the RBC.
How do you Dx G6P deficiency?
CBC retic count
Smear: Heinz bodies, bite cells
LFTs: increased bilirubin
What is the difference between Howell-Jolly and Heinz bodies?
Howell-Jolly: Nuclear remanants, found in damaged spleen (trauma, radiation, etc.) and megaloplastic anemia.
Heinz: gummed up globlin chains in thalassemias.
What factors does PT test for?
I, II,V, VII, and X
What factors does PTT test for?
Slides: II, V, VIII, IX, X, and XI
First Aid: All except VII and XIII