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Flashcards in Hemeonc 6 Deck (14)
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1
Q

Activation of platelets and formation of initial platelet plug in wall of injured vessel

A

Primary Hemostasis (PLT, PFA-platelet function assay)

2
Q

Activation of plasma coagulation factors and formation of a fibrin clot

A

Secondary Hemostasis (PT/PTT)

3
Q

Which coagulation test should be done for Extrinsic Pathway (Tissue Factor)

A

PT/INR

4
Q

Which coagulation test should be done for Intrinsic pathway

A

aPTT

5
Q
Where is your problem if you're experiencing: Superficial bleeding
Mucocutaneous bleeding
Petechiae, small ecchymoses
Immediate bleeding after trauma
Bleeding controlled by direct pressure
A

Problem with platelet plug = Primary hemostasis

Includes menstrual bleeding

6
Q

Where is your problem if you’re experiencing: Deep muscle bleeding Hemarthrosis
NOT petechiae
Delayed bleeding after trauma
Not controlled by direct pressure

A

Problem is with coagulation factors = Secondary hemostasis

7
Q

Which disorder presents with thrombocytopenia and giant platelets? Defective receptor on platelet that cannot make initial clot.

A

Bernard Soulier

8
Q

Which bleeding disorder has normal number of platelets of normal size, but has abnormal platelet aggregation and recruitment?

A

Glanzmann thrombasthenia

9
Q

Which acquired PLT disorder is characterized by low # of PLT’s due to destruction of megakaryocytes by the immune system and decreased production in the bone marrow?

A

ITP–Immune thrombocytopenia Purpura

10
Q

What is DIC?

A

Disseminated Intravascular Coagulation, aka “clotting all over the place” which means there is rapid consumption of PLT’s AND coagulation factors

11
Q

Deficit in clotting Factor VIII or IX. Which pathway does this affect?
So which test would be abnormal?

A

1) Hemophilia A and B, respectively
2) Intrinsic pathway
3) PTT only

12
Q

What does von Willebrand Factor do?

A

1) Adhesion to epithelium
2) PLT/PLT aggregation
3) Protects and transports Factor VIII

So it is necessary for primary and secondary hemostasis

13
Q

What is the most common bleeding disorder? And who is affected the most?

A

von Willebrand Disease. Males, Females, and all ethnicities get this equally

14
Q

Describe the “Type” classifications of vWD

A

type 1–75%, mild PLT-like symptoms
type 2–everything in between
type 3–abscense of vWF, severe bleeding (any female with ‘hemophilia’ symptoms likely has VWD