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Flashcards in Hemolytic Anemia Deck (10):
1

What are the lab markers for intravascular hemolytic anemia?

decrease in free haptoglobin
LDH increases

2

What are the lab markers for extravascular hemolytic anemia?

increase in indirect bilirubin
increase in LDH

3

What's the deal with cold agglutinins?

IgM (cold weather is Miserable)
occurs w/ EBV or mycoplasma
occurs w/ malignancies, such as CLL
**problem comes when there is circulation to a cold extremity

4

What's the deal with warm agglutinins?

IgG (warm weather is great)
react against RBC protein antigens at body temp
Seen iN:
EBV, HIV
Lupus
Malignancies: CLL, B cell lymphoma
Congenital Immune abnormalities

5

Describe a direct coombs test?

give patient antibodies that will bind their antibodies (already bound to RBCs) and cause agglutination

seen in hemolytic disease of newborn
drug-induced autoimmune hemolytic anemia
hemolytic transfusion reactions

6

Describe an indirect coombs test?

patient's serum given normal RBCs. if agglutinate b/c patient has free floating antibodies-->+

7

What is the treatment for paroxysmal nocturnal hemoglobinuria?

terminal complement inhibitor
eculizumab

8

Crew cut skull on X-ray is indicative of what?

thalassemias
sickle cell anemia

9

What is the treatment for sickle cell anemia?

hydroxyurea, increases hbF

10

What are some complications of sickle cell disease?

aplastic crisis w/ parvovirus B19 infection
salmonella osteomyelitis
autosplenectomy-->then howell jolly bodies b/c spleen can't get rid of them
w/o spleen-->increased risk for encapsulated organisms
splenic infarct/sequestration crisis
painful crises of vaso occlusion like dactylitis and avascular necrosis
renal papillary necrosis