Flashcards in Hemolytic Anemia Deck (10)
What are the lab markers for intravascular hemolytic anemia?
decrease in free haptoglobin
What are the lab markers for extravascular hemolytic anemia?
increase in indirect bilirubin
increase in LDH
What's the deal with cold agglutinins?
IgM (cold weather is Miserable)
occurs w/ EBV or mycoplasma
occurs w/ malignancies, such as CLL
**problem comes when there is circulation to a cold extremity
What's the deal with warm agglutinins?
IgG (warm weather is great)
react against RBC protein antigens at body temp
Malignancies: CLL, B cell lymphoma
Congenital Immune abnormalities
Describe a direct coombs test?
give patient antibodies that will bind their antibodies (already bound to RBCs) and cause agglutination
seen in hemolytic disease of newborn
drug-induced autoimmune hemolytic anemia
hemolytic transfusion reactions
Describe an indirect coombs test?
patient's serum given normal RBCs. if agglutinate b/c patient has free floating antibodies-->+
What is the treatment for paroxysmal nocturnal hemoglobinuria?
terminal complement inhibitor
Crew cut skull on X-ray is indicative of what?
sickle cell anemia
What is the treatment for sickle cell anemia?
hydroxyurea, increases hbF