Hemostasis 1 Flashcards Preview

Blood > Hemostasis 1 > Flashcards

Flashcards in Hemostasis 1 Deck (19):
1

normal hemostasis: definition

interactive process by which the blood vessel lining cells aka the vascular endothelium, platelets and clotting factors work together to stop blood flow at the site of injury

2

coagulation: what?

process by which liquid blood is converted into a solid clot

3

name for blood clot

thrombus

4

thrombosis: what? results in?

pathologic blood clotting = lack of blood flow and O2 supply to organs and tissues

5

primary hemostasis: depends on?

platelets

6

for hemostasis, what 3 conditions do you need?

normal calcium, pH and temperature.

7

3 steps to primary hemostasis

adhesion, secretion, aggregation

8

what's involved in adhesion (primary hemostasis)

platelets GpIb + vWF +collagen

9

what's involved in secretion (primary hemostasis)

TxA2, ADP and serotonin to recruit more platelets

10

what's involved in aggregation (primary hemostasis)

platelet Gp 2b3a and fibrin.

11

Lab evaluation of primary hemostasis: what 2 things do you evaluate?

platelets and vWF

12

3 things to look at when evaluating platelets for primary hemostasis

number, size/morphology, special platelet function testss

13

2 things to look at when evaluating vWF for primary hemostasis?

factor level +function

14

what is never measured in lab evaluations of hemostasis

collagen: even though it is critical!

15

secondary hemostasis: foundation? end with what two key steps?

activated platelets = foundation. thrombin (factor IIa) generation, and a stable fibrin (factor I) clot

16

extrinsic pathway steps

tissue injury activates 7, which activates X = beginning of common pathway. also activates factor 9 (last step of intrinsic)

17

lab evaluation of extrinsic pathway

PT aka prothrombin time

18

intrinsic pathway steps

activation of 12, 11, 9. 9a plus 8a and PL and calcium activate 10 then common pathway.

19

lab evaluation of intrinsic pathway

PTT aka activated partial thromboplastic time