Flashcards in Hemostasis 1 Deck (19):
normal hemostasis: definition
interactive process by which the blood vessel lining cells aka the vascular endothelium, platelets and clotting factors work together to stop blood flow at the site of injury
process by which liquid blood is converted into a solid clot
name for blood clot
thrombosis: what? results in?
pathologic blood clotting = lack of blood flow and O2 supply to organs and tissues
primary hemostasis: depends on?
for hemostasis, what 3 conditions do you need?
normal calcium, pH and temperature.
3 steps to primary hemostasis
adhesion, secretion, aggregation
what's involved in adhesion (primary hemostasis)
platelets GpIb + vWF +collagen
what's involved in secretion (primary hemostasis)
TxA2, ADP and serotonin to recruit more platelets
what's involved in aggregation (primary hemostasis)
platelet Gp 2b3a and fibrin.
Lab evaluation of primary hemostasis: what 2 things do you evaluate?
platelets and vWF
3 things to look at when evaluating platelets for primary hemostasis
number, size/morphology, special platelet function testss
2 things to look at when evaluating vWF for primary hemostasis?
factor level +function
what is never measured in lab evaluations of hemostasis
collagen: even though it is critical!
secondary hemostasis: foundation? end with what two key steps?
activated platelets = foundation. thrombin (factor IIa) generation, and a stable fibrin (factor I) clot
extrinsic pathway steps
tissue injury activates 7, which activates X = beginning of common pathway. also activates factor 9 (last step of intrinsic)
lab evaluation of extrinsic pathway
PT aka prothrombin time
intrinsic pathway steps
activation of 12, 11, 9. 9a plus 8a and PL and calcium activate 10 then common pathway.