hemostasis surgical bleeding and transfusion Flashcards Preview

Surgery PLE > hemostasis surgical bleeding and transfusion > Flashcards

Flashcards in hemostasis surgical bleeding and transfusion Deck (22):
1

4 steps in hemostasis

1. vascular constriction
2. platelet plug formation
3. fibrin formation
4. fibrinolysis

2

It is a potent constrictor of smooth muscle and is produced locally at the site of injury

thromboxane A2

3

it is a potent vasoconstrictor and is synthesized by injured endothelium and serotonin

endothelin

4

these are capable of contracting vascular smooth muscle

1. bradykinin
2. fibrinopeptides

5

What is the most common abnormality of hemostasis

thrombocytopenia

6

This is the defect of bernard soulier syndrome

1. glycoprotein Ib/IX/V receptor for vWF
2. defective platelet adhesion
3. low platelet count

7

This is the defect in Glanzmann thrombasthenias

1. glycoprotein IIb/IIIA complex
2. defective platelet aggregation
3. normal platelet count

8

how much is the expected rise in platelet in 1 unit of platelet concentrate

10,000

9

What are the cytochrome P450 inducers

Ethyl Booba takes phen phen and refuses greasy carb shakes
7 drugs

10

What are the cytochrome P450 inhibitors

inhibitors stop cyber kids from eating grapefruit Q

9 drugs

11

What is the most common complication of warfarin therapy

abdominal cavity bleeding

12

What is the most common cause of abdominal pain in patients receiving anticoagulation therapy

intramural bowel hematoma

13

It is a cytokine that stimulates proliferation of hematopoietic stem cells and megakaryocytes

IL - 11

14

most common bacteria seen in contamination of infused blood

gram negative organisms

1. yersinia enterocolitica
2. pseudomonas

15

Most bacterial contamination of infused blood is seen in what blood product

platelet

16

TRALI occurs how many hours after transfusion

1 - 2 hours and ALWAYS before 6 hours

17

What is the etiology of TRALI

related to anti HLA anti human neturophil antigen antibodies in transfused blood that pries neutrophils in the pulmonary circulation

18

What is the characteristic of acute hemolytic reaction

1. administration of ABO incompatible blood
2. intravascular hemolysis
3. monitor urine output and maintain adequate hydration

19

What is the characteristic of chronic hemolytic reaction

1. occurs 2 to 10 days after transfusion
2. extravascular hemolysis
3. does not require specific treatment

20

What percentage of platelets are sequestered by the spleen

30%

21

what is the percent of the population that is Rh negative

15%

22

What are the values that indicate that there is NO NEED for reversal of heparin or warfarin therapy

1. aPTT < 1.3
2. INR < 1.5