Flashcards in Herpes II Deck (20):
What is the primary infection of EBV?
- Asymptomatic Infection
- Infectious Mononucleosis
What cancer is EBV associated with?
- Burkitt's Lymphoma
- Nasopharyngeal Carcinoma
What is the pathogenesis of EBV?
Virus in saliva infects epithelia and spreads to B cells in lymphatics which promotes B cell growth
What cells are required to control EBV infection?
T cells - they kill and control the B cell outgrowth
What is used for EBV detection?
- Monospot test
- IgM and IgG profile to EBV antigens
Is there treatment for EBV?
What is the predominant response to CMV infection?
When can CMV infection be serious?
What causes mononucleosis and is heterophile Ab negative?
What can be used to identify CMV?
PCR, Serology, Histology
What are the treatments for CMV?
What is the problem with ganciclovir?
Bone marrow toxicity
Inhibits CMV terminase complex
- Rapid onset of high fever
- Generalized rash
What is the viral cause of roseola?
Caused by HHV6 and HHV7
How is HHV6 and HHV7 diagnosed?
What disease does HHV8 cause?
What is required for HHV8 to be serious?
Red raised lesion with spindle-shaped tumor cells and inflammatory infiltrate