Herpes II Flashcards Preview

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Flashcards in Herpes II Deck (20):
1

What is the primary infection of EBV?

- Asymptomatic Infection
- Infectious Mononucleosis

2

What cancer is EBV associated with?

- Burkitt's Lymphoma
- Nasopharyngeal Carcinoma

3

What is the pathogenesis of EBV?

Virus in saliva infects epithelia and spreads to B cells in lymphatics which promotes B cell growth

4

What cells are required to control EBV infection?

T cells - they kill and control the B cell outgrowth

5

What is used for EBV detection?

- Monospot test
- IgM and IgG profile to EBV antigens

6

Is there treatment for EBV?

No

7

What is the predominant response to CMV infection?

Asymptomatic Infection

8

When can CMV infection be serious?

Fetal/Neonatal Infection

9

What causes mononucleosis and is heterophile Ab negative?

CMV

10

What can be used to identify CMV?

PCR, Serology, Histology

11

What are the treatments for CMV?

- Ganciclovir
- Letermovir

12

What is the problem with ganciclovir?

Bone marrow toxicity

13

Letermovir MOA

Inhibits CMV terminase complex

14

Roseola

- Rapid onset of high fever
- Generalized rash

15

What is the viral cause of roseola?

Caused by HHV6 and HHV7

16

How is HHV6 and HHV7 diagnosed?

Clinical presentation

17

What disease does HHV8 cause?

Kaposi's sarcoma

18

What is required for HHV8 to be serious?

Immunocompromised state

19

Kaposi's Sarcoma

Red raised lesion with spindle-shaped tumor cells and inflammatory infiltrate

20

How is HHV8 spread?

Sexual contact

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